"...This book offers the best approach to the presentation of problems related to the treatment of the acute leukemias that I know of. The idea of having different groups of investigators give their views on the topics and the emphasis on future directions make it an important contribution to the study of leukemia. Treatment of Acute Leukemias should be read by both adult and pediatric hematologists and oncologists, and it should be required reading for trainees in these disciplines. Dr. Pui, who has already made major contributions through his own work, has added greatly to the future of the field by organizing and editing this impressive book." -New England Journal of Medicine "...comprehensive and up to date. This is one of the best books produced in recent years on the diagnosis and management of the acute leukaemias." - European Journal of Haematology

• I: Diagnosis, Classification, and Prognosis.- 1 Classification of Acute Leukemias: Perspective 1.- 2 Classification of Acute Leukemias: Perspective 2.- II: Chemotherapeutic Strategies.- 3 Biology and Treatment of Infant Leukemias: Perspective 1.- 4 Biology and Treatment of Acute Leukemias in Infants: Perspective 2.- 5 Treatment of Childhood Acute Lymphoblastic Leukemia.- 6 Treatment of Childhood Acute Lymphoblastic Leukemia: The Dana-Farber Cancer Institute ALL Consortium Perspective.- 7 Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: Lessons Learned and Future Directions.- 8 Treatment of Adolescents and Young Adults with Acute Lymphoblastic Leukemia: Children’s Cancer Group Trials.- 9 Treatment of Adult Acute Lymphoblastic Leukemia: Perspective 1.- 10 Treatment of Adult Acute Lymphoblastic Leukemia: Perspective 2.- 11 Central Nervous System—Directed Therapy for Acute Lymphoblastic Leukemia.- 12 Diagnosis, Prophylaxis, and Treatment of Central Nervous System Involvement in Acute Lymphoblastic Leukemia.- 13 Treatment of Relapsed Acute Lymphoblastic Leukemia: Perspective 1.- 14 Treatment of Relapsed Acute Lymphoblastic Leukemia: Perspective 2.- 15 Treatment of B-Cell Acute Lymphoblastic Leukemia: Perspective 1.- 16 Treatment of B-Cell Acute Lymphoblastic Leukemia: Perspective 2.- 17 Treatment of Acute Myeloid Leukemia in Children.- 18 Treatment of Childhood Acute Myeloid Leukemia.- I. Acute Myeloid Leukemia in Adults.- 19 Therapy of Acute Myeloid Leukemia in Adults.- 20 Treatment of Adult Acute Myelogenous Leukemia.- J. Acute Promyelocytic Leukemia.- 21 Acute Promyelocytic Leukemia: Perspective 1.- 22 Acute Promyelocytic Leukemia: Perspective 2.- K. Childhood Leukemias in Underprivileged Countries.- 23 Treatment of Childhood Leukemias inUnderprivileged Countries.- 24 How to Confront the Problem of Treatment of Childhood Leukemias in Underprivileged Populations.- III: Antileukemic Drugs.- 25 Rationale for High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia.- 26 Role of Methotrexate in the Treatment of Acute Lymphoblastic Leukemia.- 27 Asparaginase.- 28 Asparaginase Treatment.- 29 Antipurines in Childhood Acute Lymphoblastic Leukemia.- 30 Antipurines.- 31 Etoposide in Acute Leukemias: Therapeutic and Pharmacokinetic Considerations.- 32 Etoposide and Teniposide: Clinical Applications with a Focus on Leukemia.- IV: Hematopoietic Stem Cell Transplantation.- 33 Hematopoietic Stem Cell Transplantation: Perspective 1.- 34 Hematopoietic Stem Cell Transplantation: Perspective 2.- V: Biologic Treatments.- 35 Hematopoietic Growth Factors in Patients with Acute Leukemia.- 36 Hematopoietic Growth Factor Treatment in Leukemia.- 37 Immunotherapy of Leukemia.- 38 Therapy of Acute Leukemia with Monoclonal Antibodies and Immunoconjugates.- VI: Drug Resistance.- 39 Drug Resistance in Acute Leukemias.- 40 Drug Resistance in Acute Leukemia.- VII: Minimal Residual Disease.- 41 Minimal Residual Disease.- 42 Molecular Monitoring of Minimal Residual Disease.

"...This book offers the best approach to the presentation of problems related to the treatment of the acute leukemias that I know of. The idea of having different groups of investigators give their views on the topics and the emphasis on future directions make it an important contribution to the study of leukemia. Treatment of Acute Leukemias should be read by both adult and pediatric hematologists and oncologists, and it should be required reading for trainees in these disciplines. Dr. Pui, who has already made major contributions through his own work, has added greatly to the future of the field by organizing and editing this impressive book." -New England Journal of Medicine "...comprehensive and up to date. This is one of the best books produced in recent years on the diagnosis and management of the acute leukaemias." - European Journal of Haematology

• I: Diagnosis, Classification, and Prognosis.- 1 Classification of Acute Leukemias: Perspective 1.- 2 Classification of Acute Leukemias: Perspective 2.- II: Chemotherapeutic Strategies.- 3 Biology and Treatment of Infant Leukemias: Perspective 1.- 4 Biology and Treatment of Acute Leukemias in Infants: Perspective 2.- 5 Treatment of Childhood Acute Lymphoblastic Leukemia.- 6 Treatment of Childhood Acute Lymphoblastic Leukemia: The Dana-Farber Cancer Institute ALL Consortium Perspective.- 7 Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: Lessons Learned and Future Directions.- 8 Treatment of Adolescents and Young Adults with Acute Lymphoblastic Leukemia: Children’s Cancer Group Trials.- 9 Treatment of Adult Acute Lymphoblastic Leukemia: Perspective 1.- 10 Treatment of Adult Acute Lymphoblastic Leukemia: Perspective 2.- 11 Central Nervous System—Directed Therapy for Acute Lymphoblastic Leukemia.- 12 Diagnosis, Prophylaxis, and Treatment of Central Nervous System Involvement in Acute Lymphoblastic Leukemia.- 13 Treatment of Relapsed Acute Lymphoblastic Leukemia: Perspective 1.- 14 Treatment of Relapsed Acute Lymphoblastic Leukemia: Perspective 2.- 15 Treatment of B-Cell Acute Lymphoblastic Leukemia: Perspective 1.- 16 Treatment of B-Cell Acute Lymphoblastic Leukemia: Perspective 2.- 17 Treatment of Acute Myeloid Leukemia in Children.- 18 Treatment of Childhood Acute Myeloid Leukemia.- I. Acute Myeloid Leukemia in Adults.- 19 Therapy of Acute Myeloid Leukemia in Adults.- 20 Treatment of Adult Acute Myelogenous Leukemia.- J. Acute Promyelocytic Leukemia.- 21 Acute Promyelocytic Leukemia: Perspective 1.- 22 Acute Promyelocytic Leukemia: Perspective 2.- K. Childhood Leukemias in Underprivileged Countries.- 23 Treatment of Childhood Leukemias inUnderprivileged Countries.- 24 How to Confront the Problem of Treatment of Childhood Leukemias in Underprivileged Populations.- III: Antileukemic Drugs.- 25 Rationale for High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia.- 26 Role of Methotrexate in the Treatment of Acute Lymphoblastic Leukemia.- 27 Asparaginase.- 28 Asparaginase Treatment.- 29 Antipurines in Childhood Acute Lymphoblastic Leukemia.- 30 Antipurines.- 31 Etoposide in Acute Leukemias: Therapeutic and Pharmacokinetic Considerations.- 32 Etoposide and Teniposide: Clinical Applications with a Focus on Leukemia.- IV: Hematopoietic Stem Cell Transplantation.- 33 Hematopoietic Stem Cell Transplantation: Perspective 1.- 34 Hematopoietic Stem Cell Transplantation: Perspective 2.- V: Biologic Treatments.- 35 Hematopoietic Growth Factors in Patients with Acute Leukemia.- 36 Hematopoietic Growth Factor Treatment in Leukemia.- 37 Immunotherapy of Leukemia.- 38 Therapy of Acute Leukemia with Monoclonal Antibodies and Immunoconjugates.- VI: Drug Resistance.- 39 Drug Resistance in Acute Leukemias.- 40 Drug Resistance in Acute Leukemia.- VII: Minimal Residual Disease.- 41 Minimal Residual Disease.- 42 Molecular Monitoring of Minimal Residual Disease.

"...This book offers the best approach to the presentation of problems related to the treatment of the acute leukemias that I know of. The idea of having different groups of investigators give their views on the topics and the emphasis on future directions make it an important contribution to the study of leukemia. Treatment of Acute Leukemias should be read by both adult and pediatric hematologists and oncologists, and it should be required reading for trainees in these disciplines. Dr. Pui, who has already made major contributions through his own work, has added greatly to the future of the field by organizing and editing this impressive book." -New England Journal of Medicine "...comprehensive and up to date. This is one of the best books produced in recent years on the diagnosis and management of the acute leukaemias." - European Journal of Haematology

• I: Diagnosis, Classification, and Prognosis.- 1 Classification of Acute Leukemias: Perspective 1.- 2 Classification of Acute Leukemias: Perspective 2.- II: Chemotherapeutic Strategies.- 3 Biology and Treatment of Infant Leukemias: Perspective 1.- 4 Biology and Treatment of Acute Leukemias in Infants: Perspective 2.- 5 Treatment of Childhood Acute Lymphoblastic Leukemia.- 6 Treatment of Childhood Acute Lymphoblastic Leukemia: The Dana-Farber Cancer Institute ALL Consortium Perspective.- 7 Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: Lessons Learned and Future Directions.- 8 Treatment of Adolescents and Young Adults with Acute Lymphoblastic Leukemia: Children’s Cancer Group Trials.- 9 Treatment of Adult Acute Lymphoblastic Leukemia: Perspective 1.- 10 Treatment of Adult Acute Lymphoblastic Leukemia: Perspective 2.- 11 Central Nervous System—Directed Therapy for Acute Lymphoblastic Leukemia.- 12 Diagnosis, Prophylaxis, and Treatment of Central Nervous System Involvement in Acute Lymphoblastic Leukemia.- 13 Treatment of Relapsed Acute Lymphoblastic Leukemia: Perspective 1.- 14 Treatment of Relapsed Acute Lymphoblastic Leukemia: Perspective 2.- 15 Treatment of B-Cell Acute Lymphoblastic Leukemia: Perspective 1.- 16 Treatment of B-Cell Acute Lymphoblastic Leukemia: Perspective 2.- 17 Treatment of Acute Myeloid Leukemia in Children.- 18 Treatment of Childhood Acute Myeloid Leukemia.- I. Acute Myeloid Leukemia in Adults.- 19 Therapy of Acute Myeloid Leukemia in Adults.- 20 Treatment of Adult Acute Myelogenous Leukemia.- J. Acute Promyelocytic Leukemia.- 21 Acute Promyelocytic Leukemia: Perspective 1.- 22 Acute Promyelocytic Leukemia: Perspective 2.- K. Childhood Leukemias in Underprivileged Countries.- 23 Treatment of Childhood Leukemias inUnderprivileged Countries.- 24 How to Confront the Problem of Treatment of Childhood Leukemias in Underprivileged Populations.- III: Antileukemic Drugs.- 25 Rationale for High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia.- 26 Role of Methotrexate in the Treatment of Acute Lymphoblastic Leukemia.- 27 Asparaginase.- 28 Asparaginase Treatment.- 29 Antipurines in Childhood Acute Lymphoblastic Leukemia.- 30 Antipurines.- 31 Etoposide in Acute Leukemias: Therapeutic and Pharmacokinetic Considerations.- 32 Etoposide and Teniposide: Clinical Applications with a Focus on Leukemia.- IV: Hematopoietic Stem Cell Transplantation.- 33 Hematopoietic Stem Cell Transplantation: Perspective 1.- 34 Hematopoietic Stem Cell Transplantation: Perspective 2.- V: Biologic Treatments.- 35 Hematopoietic Growth Factors in Patients with Acute Leukemia.- 36 Hematopoietic Growth Factor Treatment in Leukemia.- 37 Immunotherapy of Leukemia.- 38 Therapy of Acute Leukemia with Monoclonal Antibodies and Immunoconjugates.- VI: Drug Resistance.- 39 Drug Resistance in Acute Leukemias.- 40 Drug Resistance in Acute Leukemia.- VII: Minimal Residual Disease.- 41 Minimal Residual Disease.- 42 Molecular Monitoring of Minimal Residual Disease.