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Beskrivning
An authoritative collection of optimal techniques for producing and characterizing the immunologically active cells and effector molecules now gaining wide use in the clinical treatment of patients.
"...a comprehensive and authoritative collection of currently used protocols for adoptive immunotherapy in both pre-clinical and clinical settings." - Immunology News "...will be not only useful for basic researchers but also clinical scientists aiming to translate basic research to a clinical setting." - Immunology and Cell Biology
Innehållsförteckning
Exploiting Dendritic Cells for Active Immunotherapy of Cancer and Chronic Infection.- A Mathematical Approach for Optimizing Dendritic Cell-Based Immunotherapy.- Delivery of Tumor Antigens to Dendritic Cells Using Biodegradable Microspheres.- RNA Transfection of Dendritic Cells.- Isolation and Generation of Clinical-Grade Dendritic Cells Using the CliniMACS System.- Generation of Clinical-Grade Monocyte-Derived Dendritic Cells Using the CliniMACS System.- Adenoviral Transduction of Dendritic Cells.- Generation of Autologous Peptide- and Protein-Pulsed Dendritic Cells for Patient-Specific Immunotherapy.- Phenotypical and Functional Characterization of Clinical-Grade Dendritic Cells.- Dendritic Cells in Clinical Trials for Multiple Myeloma.- Identification of Tumor-Associated Autoantigens With SEREX.- Application of Proteomics and Protein Analysis for Biomarker and Target Finding for Immunotherapy.- Isolation and Expansion of Tumor-Reactive Cytotoxic T-Cell Clones for Adoptive Immunotherapy.- Tracking Adoptively Transferred Antigen-Specific T-Cells With Peptide/MHC Multimers.- Gene Transfer of MHC-Restricted Receptors.- Immunotherapy With CTL Restricted by Nonself MHC.- Designing TCR for Cancer Immunotherapy.- Isolation and Expansion of Tumor-Specific CD4+T-Cells by Means of Cytokine Secretion.- Methods for the Ex Vivo Characterization of Human CD8+T Subsets Based on Gene Expression and Replicative History Analysis.- Regulatory T-Cells in Antitumor Therapy Isolation and Functional Testing of CD4+CD25+Regulatory T-Cells.- Monoclonal Antibody-Based Strategies in Autoimmunity and Transplantation.- Producing Bispecific and Bifunctional Antibodies.- Antibody-Cytokine Fusion Proteins for the Therapy of Cancer.- Synthesis and Biological Evaluation of a Paclitaxel Immunoconjugate.- Cytotoxic Tumor Targeting With scFv Antibody-Modified Liposomes.- Intravenous Immunoglobulin Treatment for Fibrosis, Atherosclerosis, and Malignant Conditions.- Study of T-Cell Costimulatory Blockade In Vivo at a Single-Cell Level.- Stem Cell Transplantation: Graft-Mediated Antileukemia Effects.- Influence of Radiation Protocols on Graft-vs-Host Disease Incidence After Bone-Marrow Transplantation in Experimental Models.- Induction of Chimerism and Tolerance Using Freshly Purified or Cultured Hematopoietic Stem Cells in Nonmyeloablated Mice.- Induction of Mixed vs Full Chimerism to Potentiate GVL Effects After Bone-Marrow Transplantation.- Application of Donor Lymphocytes Expressing a Suicide Gene for Early GVL Induction and Later Control of GVH Reactions After Bone-Marrow Transplantation.
