Gene Therapy of Cancer

From the reviews of the second edition: "This book, authored by a number of prominent researchers in the field ... provides an overview of recent ground-breaking experimental and clinical concepts and protocols in cancer gene therapy. ... the editors and authors are to be commended for producing a well-organised, authoritative and succinct coverage of the vast area of gene therapy protocols. The materials are relevant, easy-to-follow and well-presented with good illustrations. Without doubt it will serve as a useful resource for those interested in this field, both scientists and clinicians ... ."--- (Han Hsi Wong and Yaohe Wang, Human Genetics, Vol. 128, July, 2010)

• Experimental Approaches in Cancer Gene Therapy: Introduction.- The Development of Gene Therapy: From Monogenic Recessive Disorders to Complex Diseases Such as Cancer.- Vectorology for Cancer Gene Therapy.- Designing Adenoviral Vectors for Tumor-Specific Targeting.- Analysis of HSV Oncolytic Virotherapy in Organotypic Cultures.- Use of Minicircle Plasmids for Gene Therapy.- Transposable Elements as Plasmid-Based Vectors for Long-Term Gene Transfer into Tumors.- Designing Plasmid Vectors.- Development of Bacterial Vectors for Tumor-Targeted Gene Therapy.- Nonviral Transfer Technologies in Cancer Gene Therapy.- Electroporative Gene Transfer.- Gene Gun Delivery Systems for Cancer Vaccine Approaches.- Ultrasound-Mediated Gene Transfection.- Nonviral Jet-Injection Technology for Intratumoral In Vivo Gene Transfer of Naked DNA.- Experimental Studies in Cancer Gene Therapy.- Methods for Constructing and Evaluating Antitumor DNA Vaccines.- Immunity of Lentiviral Vector-Modified Dendritic Cells.- Saporin Suicide Gene Therapy.- Using In Vivo Biopanning for the Development of Radiation-Guided Drug Delivery Systems.- Chemosensitization of Tumor Cells: Inactivation of Nuclear Factor-Kappa B Associated with Chemosensitivity in Melanoma Cells After Combination Treatment with E2F-1 and Doxorubicin.- Induction of Tumor Cell Apoptosis by TRAIL Gene Therapy.- Silencing Epidermal Growth Factor Receptor by RNA Interference in Glioma.- Delivery of Phosphorodiamidate Morpholino Antisense Oligomers in Cancer Cells.- Use of RNA Aptamers for the Modulation of Cancer Cell Signaling.- G-Rich Oligonucleotides for Cancer Treatment.- Clinical Approaches in Cancer Gene Therapy - Requirements for Clinical Gene Therapy Trials.- Regulatory Aspects for Translating Gene Therapy Research into the Clinic.- Ethics of Cancer Gene Transfer Clinical Research.- Virus Production for Clinical Gene Therapy.- Production of Plasmid DNA as Pharmaceutical.- Clinical Protocols in Cancer Gene Therapy.- Gene Immunotherapy for Non-Small Cell Lung Cancer.- Gene Therapy for Antitumor Vaccination.- HSV-tk/IL-2 Gene Therapy for Glioblastoma Multiforme.- Construction and Characterization of an Oncolytic HSV Vector Containing a Fusogenic Glycoprotein and Prodrug Activation for Enhanced Local Tumor Control.- Newcastle Disease Virus: A Promising Vector for Viral Therapy, Immune Therapy, and Gene Therapy of Cancer.- Oncolytic Viral Therapy Using Reovirus.- Design and Testing of Novel Oncolytic Vaccinia Strains.- Tumor-Targeted Salmonella typhimurium Overexpressing Cytosine Deaminase: A Novel, Tumor-Selective Therapy.- Chemoprotection by Transfer of Resistance Genes.- Phase I Clinical Trial of Locoregional Administration of the Oncolytic Adenovirus ONYX-015 in Combination with Mitomycin-C, Doxorubicin, and Cisplatin Chemotherapy in Patients with Advanced Sarcomas.