DNA-encoded Library Technology for Drug Discovery

Inbunden, Engelska, 2025

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Beskrivning

DNA-encoded libraries have numerous advantages over traditional screening methods, including easy identification of compounds and the large quantity of compounds that can be screened simultaneously.This book provides a comprehensive guide to the implementation of DNA-encoded library technology (DELT) in drug discovery for screening and hit validation, illustrated with successful case studies.A valuable resource for researchers in drug discovery, this book is complete with successful case studies to illustrate the best practice in implementation and operation of DELT.

Produktinformation

Utgivningsdatum:2025-02-21
Mått:156 x 234 x 11 mm
Vikt:427 g
Format:Inbunden
Språk:Engelska
Serie:Drug Discovery Series
Antal sidor:166
Förlag:Royal Society of Chemistry
ISBN:9781788014878

Utforska kategorier

Farmakologi inom Medicin
Organisk kemi inom Naturvetenskap och teknik

Mer om författaren

Purdue University, USA Dr Jin Li has over 30 years biopharmaceutical experience (at Protherics and AstraZeneca), with senior scientific and leadership roles in early stage research; as well as experience in initiating and leading major collaboration, research and outsourcing programmes. Before founding HitGen, he held Global Director positions of Compound Sciences and Computational Sciences at AstraZeneca. This included responsibility for computational chemistry, computational biology and compound collection enhancement. Dr Li completed his BSc at Sichuan University, and PhD in macromolecular sciences at Aston University. He then completed post-doctoral research in theoretical biochemistry at Manchester University, UK. Dr Li is also a Fellow of the Royal Society of Chemistry.

Innehållsförteckning

Overview of Affinity-based DEL Selections with Select Target Types and AchievementsMachine Learning with DEL Selection Data and for DEL designOne bead one compound (OBOC) DELs for Biochemical ScreensLive cell-based DEL SelectionsOn-DNA Medicinal Chemistry: Focused libraries, fragment expansion, and hit optimizationDELs with Covalent WarheadsApplication of DELs for E3 Ligase Ligand and PROTAC development