Drug Discovery Series – serie
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96 produkter
Industrialization of Drug Discovery
From Target Selection Through Lead Optimization
Inbunden, 2005
3550 kr
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The drug discovery and development process is getting longer, more expensive, and no better. The industry suffers from the same clinical attrition and safety-related market withdrawal rates today as it did 20 years ago. Industrialization of Drug Discovery: From Target Selection Through Lead …
Industrialization of Drug Discovery
From Target Selection Through Lead Optimization
Häftad, 2021
821 kr
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The drug discovery and development process is getting longer, more expensive, and no better. The industry suffers from the same clinical attrition and safety-related market withdrawal rates today as it did 20 years ago. Industrialization of Drug Discovery: From Target Selection Through Lead …
Phage Display In Biotechnology and Drug Discovery
Av Sachdev S. Sidhu, Clarence Ronald Geyer
Häftad, 2017
1259 kr
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Phage Display in Biotechnology and Drug Discovery, Second Edition provides a comprehensive view of the impact and promise of phage display in drug discovery and biotechnology. Building on the success of its previous edition, the book discusses current theories, principles, and methods in the field …
Methods in Microarray Normalization
Inbunden, 2008
1811 kr
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Scientists can use molecular profiling microarrays to compare healthy cells with their diseased counterparts and develop gene-specific treatments. Finding the best way to interpret original profiling data into accurate trends, however, continues to drive the development of normalization algorithms …
Phage Display In Biotechnology and Drug Discovery
Av Sachdev S. Sidhu, Clarence Ronald Geyer
Inbunden, 2015
3550 kr
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Phage Display in Biotechnology and Drug Discovery, Second Edition provides a comprehensive view of the impact and promise of phage display in drug discovery and biotechnology. Building on the success of its previous edition, the book discusses current theories, principles, and methods in the field …
Biochips as Pathways to Drug Discovery
Av Andrew Carmen, Gary Hardiman
Inbunden, 2006
1219 kr
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In the fiercely competitive pharmaceutical marketplace, your organization cannot afford to spend excess dollars developing drugs that will fail to get FDA approval or have profoundly poor characteristics. Biochips as Pathways to Drug Discovery takes a comprehensive look at how the industry faces …
Handbook of Assay Development in Drug Discovery
Inbunden, 2006
3814 kr
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The need to screen targets faster and more efficiently, coupled with advances in parallel and multiplex chemical synthesis, has contributed to the increasing use of multiwell assays for drug discovery. The Handbook of Assay Development in Drug Discovery is a reference that describes the complete …
In Silico Technologies in Drug Target Identification and Validation
Inbunden, 2006
3927 kr
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The pharmaceutical industry relies on numerous well-designed experiments involving high-throughput techniques and in silico approaches to analyze potential drug targets. These in silico methods are often predictive, yielding faster and less expensive analyses than traditional in vivo or in vitro …
Drug Discovery for Schizophrenia
Inbunden, 2015
3102 kr
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Since the pioneering pharmacotherapy for treatment of schizophrenia in the 1950s by antipsychotics, only a few major innovations have been made, pointing to a general stagnation in the field of pharmacology of schizophrenia. Drug Discovery for Schizophrenia covers new insights in the field of …
Privileged Scaffolds in Medicinal Chemistry
Design, Synthesis, Evaluation
Av Stefan Bräse
Inbunden, 2015
3357 kr
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One strategy to expedite the discovery of new drugs, a process that is somewhat slow and serendipitous, is the identification and use of privileged scaffolds. This book covers the history of the discovery and use of privileged scaffolds and addresses the various classes of these important molecular …
Drug Transporters
Volume 1: Role and Importance in ADME and Drug Development
Av Glynis Nicholls, Kuresh Youdim
Inbunden, 2016
3357 kr
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Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. In this first volume on Drug Transporters, the current knowledge and techniques in the transporter sciences and their relations to drug metabolism and …
Small-molecule Transcription Factor Inhibitors in Oncology
Av Khondaker Miraz Rahman, David Thurston
Inbunden, 2018
2888 kr
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Oncogenic transcription factors are an increasingly important target for anticancer therapies. Inhibiting these transcription factors could allow tumour cells to be "reprogrammed", leading to apoptosis or differentiation from the malignant phenotype. As the use of kinase inhibitors is gradually …
Antibiotic Drug Discovery
New Targets and Molecular Entities
Av Steven M Firestine, Troy Lister
Inbunden, 2017
3170 kr
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Recent years have seen a resurgence of antibiotic drug discovery. This book brings together the relevant information to assess the state-of-the-art. It identifies and elaborates the most recent and compelling strategies for antibiotic drug discovery with a primary focus on new targets, mechanisms …
Allosterism in Drug Discovery
Av Dario Doller
Inbunden, 2016
3285 kr
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Although the concept of allosterism has been known for over half a century, its application in drug discovery has exploded in recent years. The emergence of novel technologies that enable molecular-level ligand-receptor interactions to be studied in studied in unprecedented detail has driven this …
Theranostics and Image Guided Drug Delivery
Av Maya Thanou
Inbunden, 2018
3395 kr
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Molecular imaging of drugs or drug carriers is a valuable tool that can provide important information on spatiotemporal distribution of drugs, allowing improved drug distribution at target sites. Chemically labelled drugs can be used to both diagnose and treat diseases. This book introduces the …
Peptide-based Drug Discovery
Challenges and New Therapeutics
Inbunden, 2017
3296 kr
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With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it …
Biophysical Techniques in Drug Discovery
Inbunden, 2017
2897 kr
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Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays. This book provides an overview of the biophysical methods applied in drug …
Synthetic Methods in Drug Discovery
Complete Set
Av David C Blakemore, Yvette M Fobian m. fl.
2016
6622 kr
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The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like properties, it is important to know which synthetic methodologies will give the best results. This two-volume set of books provides both …
Drug Transporters
Role and Importance in ADME and Drug Development Complete Set
Av Glynis Nicholls, Kuresh Youdim
2016
5341 kr
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Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. This two volume set of books comprehensively reviews current knowledge and techniques in the transporter sciences and their relations to drug …
Drug Discovery for Leishmaniasis
Av Luis Rivas, Carmen Gil
Inbunden, 2017
2320 kr
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For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing …
Therapies for Retinal Degeneration
Targeting Common Processes
Av Enrique J de la Rosa, Thomas G Cotter
Inbunden, 2018
2737 kr
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Sight loss and blindness is a very prevalent cause of disability. Retinal diseases leading to visual loss affect many people worldwide and the search for adequate drugs remains a challenge and an important area of interest in the drug discovery field. This book addresses approaches to the treatment …
Acute Brain Impairment
Scientific Discoveries and Translational Research
Av Philip V Peplow, Svetlana A Dambinova m. fl.
Inbunden, 2017
2797 kr
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A rise in the number of young and old patients suffering from a stroke or traumatic brain injury has led to the need for better drug development and treatment, as well as diagnosis and prevention of ischemic stroke and traumatic brain injury. This book provides a comprehensive overview of …
Cytotoxic Payloads for Antibody–Drug Conjugates
Av David Thurston, Paul J M Jackson
Inbunden, 2019
3357 kr
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Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (Kadcyla™), brentuximab vedotin (Adcetris™), inotuzumab ozogamicin (Besponsa™), gemtuzumab ozogamicin …
Kinase Drug Discovery
Modern Approaches
Av Richard A Ward, Frederick W Goldberg
Inbunden, 2018
3102 kr
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Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a …
Protein–Protein Interaction Regulators
Inbunden, 2020
2984 kr
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New genomic information has revealed the crucial role that protein–protein interactions (PPIs) play in regulating numerous cellular functions. Aberrant forms of these interactions are common in numerous diseases and thus PPIs have emerged as a vast class of critical drug targets. Despite the …
Advances in Nucleic Acid Therapeutics
Av Sudhir Agrawal, Michael J Gait
Inbunden, 2019
3622 kr
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The sequencing of the human genome and subsequent elucidation of the molecular pathways that are important in the pathology of disease have provided unprecedented opportunities for the development of new therapeutics. Nucleic acid-based drugs have emerged in recent years to yield extremely …
Medicinal Chemist's Guide to Solving ADMET Challenges
Inbunden, 2021
3023 kr
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The Medicinal Chemist’s Guide to Solving ADMET Challenges summarizes a series of design strategies and tactics that have been successfully employed across pharmaceutical and academic laboratories to solve common ADMET issues. These are exemplified with a curated collection of concrete examples …
MicroRNAs in Diseases and Disorders
Emerging Therapeutic Targets
Av Philip V Peplow, Bridget Martinez m. fl.
Inbunden, 2019
3357 kr
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From pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets …
Peptide Therapeutics
Strategy and Tactics for Chemistry, Manufacturing, and Controls
Inbunden, 2019
3395 kr
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Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to …
Emerging Drugs and Targets for Multiple Sclerosis
Av Ana Martinez
Inbunden, 2019
2919 kr
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Multiple sclerosis (MS) is a complex disease with a presumed autoimmune aetiology and few current effective treatments. Disease modifying therapies focus on the altering the natural course of relapsing and remitting MS, targeting the inflammatory response. Other targets involve tacking the cause of …
