Carmen Gil - Böcker

For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the only treatment option for the bulk of patients. However, this is largely unaffordable for most. In the past three years numerous advances in drug discovery have been made for treating this disease by exploiting diverging metabolic pathways between the Leishmania enzymes and their hosts, using nanotechnology to target the immune cell phagolysosomes where Leishmania resides.Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania.Recent studies have shown that leishmaniasis affects some of the poorest people in the world, with 95% of fatal cases occurring in only 6 countries. With the WHO goal of eliminating this public health problem in the South-east Asia Region by 2020, this book will be important for anyone who is interested in neglected tropical diseases.

Affecting over 1.5 million people across the world, Parkinson's disease is a progressive neurological condition characterized, in part, by the loss of dopaminergic neurons in the substantia nigra pars compacta. It affects 1.5% of the global population over 65 years of age. As life expectancy is increasing, over the next few years the number of patients with Parkinson´s disease will grow exponentially. To date, there are no available treatments that are capable of curing Parkinson´s disease, and the current goal of therapy, dopamine replacement strategies, is to reduce symptoms. After several years of disease progression, treatment is complicated by the onset of motor fluctuations and dyskinesias. This information reveals the great importance and social need of finding an effective therapeutic intervention for Parkinson´s disease. This exemplary new book reviews some of the most outstanding examples of new drugs currently in pharmaceutical development or new targets currently undergoing the validation process to try to reach the Parkinson´s drug market in the next few years as potential disease modifying drugs. Providing up to date and comprehensive coverage, this book is essential reading for researchers working in academia and industry in any aspect of medicinal chemistry or drug discovery.

When Princess Nona has simply had enough of being a princess, she leaves her parents' palace and takes her destiny into her own hands, searching for a way of life that's more to her liking. After all, being a fairytale princess isn't easy. She can't make mistakes, or yawn, or scratch her nose. She must be discreet, play the harpsichord, smile all the time, and wait for her Prince Charming to arrive. Children will follow along on Nona's adventures as she tries new things and meets new people, until she finally figures out what makes her happy. This story written in verse emphasizes values such as equality, the importance of being oneself, and having the courage to follow one's dreams. Cuando la princesa Nona se harta de ser princesa, abandona el palacio de sus padres y toma control de su propio destino, yendo en busca de un estilo de vida que le plazca mas. Pues al fin y al cabo, ser una princesa de cuentos de hadas no es facil. No puede cometer errores, o bostezar, o rascarse la nariz. Tiene que ser muy discreta, tocar el clave, sonreir todo el tiempo y esperar la llegada de su Principe Azul.Los jovenes lectores seguiran las aventuras de Nona mientras prueba cosas nuevas y conoce a gente nueva, hasta que por fin descubre lo que la hace feliz. Esta historia escrita en verso enfatiza valores tales como la igualdad, la importancia de ser uno mismo y tener el valor necesario para ir en busca de los suenos propios.

Anastasia, formerly a princess thanks to the fairy Brunilda's magic wand, is now an everyday cockroach with a big heart, determined to do good. She dreams of becoming a famous, important figure like her distant relatives, the Egyptian scarab beetles who are treated like royalty. After some exciting adventures in her new incarnation--including saving the lives of an entire human family--Anastasia realizes it's not so bad being an ordinary cockroach after all. Will Brunilda reward Anastasia for her generous deeds? This humorous tale of self-acceptance and unity is sure to have children seeing cockroaches in a new light. Anastasia, anteriormente una princesa gracias a la varita magica del hada Brunilda, ahora es una cucaracha cualquiera con un corazon grande, empenada en hacer el bien. Suena con ser famosa e importante como sus parientes lejanos, los escarabajos egipcios que son tratados a cuerpo de rey. Despues de algunas aventuras emocionantes en su nueva encarnacion--incluyendo cuando le salva la vida a una familia de seres humanos--Anastasia se da cuenta de que ser una cucaracha comun y corriente no esta tan mal despues de todo.'Recompensara Brunilda a Anastasia por sus generosas acciones? Esta historia humoristica que trata sobre la aceptacion de uno mismo y la solidaridad hara que los ninos vean a las cucarachas con otros ojos.

Winner at the 2012 International Latino Book Awards. A superbly illustrated original story about the power of loving yourself and finding happiness.This is the story of Anastasia, a cockroach who dreamed of being accepted and becoming famous and important like her distant relatives the Egyptian beetles, sacred insects that everybody treated like royalty.Although it may seem impossible to believe, in another life Anastasia was a princess, transformed by a wave of the magic wand of Fairy Brunhilda, who was determined to sow good wherever she went. But being a princess is not an easy task… Soon Anastasia began to feel out of place. She didn’t like life in the palace too much, and after following exciting adventures, Anastasia came to understand that being an ordinary, everyday cockroach wasn’t such a bad thing after all. Especially when, moved by her great heart, she managed to save the lives of an entire family of humans, everything without getting a hair out of place! What prize did Fairy Brunhilda have in store for her as a reward for her generous actions?

Imagine being always told what to do, what to look like and not having the chance to choose. Follow this dauntless adventure and discover a story in bright, musical verse that transmits values such as equality and having the courage to follow your dreams.Nona is a princess who lives in a great palace, but she is not happy. Being a princess is not as easy as it seems… To begin with, a princess cannot make mistakes, nor yawn, nor scratch her nose… Furthermore, she must be discreet, always smile and wait patiently for her prince charming to arrive. It's such a boring job. It’s a pain to be a princess! Nona dreams of escaping from the palace and finding her purpose, although she still doesn't know what this is. Therefore, she decides to leave the court in search of adventure. Outside the palace, she will have to follow her own path until she finds who she is meant to be and, thus, takes over her own destiny.

One morning, a purple dragon flies in through Kibo's window. In fright, the little boy runs off to some truly extraordinary places, but when he returns home and looks in the mirror, the dragon is still there -- and he's right behind him! This time, though, he's a little more purple and a little bigger than the last time Kibo saw him. Maybe if he keeps running away Kibo will be able to escape the dragon! But what if that doesn't work? How will he finally defeat such a terrible monster? Kibo y el dragon morado is an entertaining tale that thelps children face up to and overcome their fears. Lexile Level 780L

Gold Medal Winner at the 2017 Moonbeam Children's Book AwardsEverybody in the farmyard loves Daisy the donkey, but as she gets older, she becomes weaker, less agile, and can’t hear so well. Then, one day, a beautiful pony full of life and energy arrives at the farm and captures everyone’s attention.In this charming tale, readers will discover the value of the experience and wisdom we learn with the passing of the years.Guided Reading Level: M, Lexile Level: 650L

Madam Hortensia followed her routine to a tee, until one day everything went wrong… what a disaster! A wonderful story, full of humor, about the importance of tackling new challenges. Do you dare to change?Madam Hortensia lives life in a straight line, never straying a step out of her daily routine.  Was she finicky? Not quite, she just liked everything to be perfectly to her liking. Her alarm clock rang every day at 07:18 sharp. Not one minute before, or one minute after. Then her planned routine would begin in extreme detail, and nothing could possibly go wrong. But one morning, her alarm does not go off on time and her life spins into a whirlwind. Suddenly, she finds herself doing entirely new things she has never tried before.With wit and charm, this delightful tale shares what happens when we learn to embrace change and open our minds to possibility.Doña Hortensia seguía su rutina al pie de la letra hasta que un día todo se torció… ¡menudo desastre! Un cuento maravilloso, lleno de humor, sobre la importancia de abordar nuevos retos. ¿Te atreves a cambiar?Para Doña Hortensia cada día era igual y lo vivía sin salirse ni un milímetro de su rutina habitual. ¿Era perfeccionista? No exactamente; simplemente le gustaban que todo estuviera perfectamente a su gusto. Cada mañana se levantaba a las 07:18 en punto; ni un minuto antes, ni un minuto después. Entonces empezaba su rutina planificada en extremo detalle, y nada podía fallar. Hasta que, una mañana, la alarma del despertador no sonó a la misma hora y… ¡Todo lo que ocurrió después fue como un torbellino que le despeinó las ideas! De repente, se encontró disfrutando de situaciones nuevas que antes ni siquiera hubiese podido imaginar.Una divertida historia que nos muestra, con ingenio y sentido del humor, lo que ocurre cuando nos atrevemos a abandonar nuestra zona de confort y abrimos la mente a nuevas posibilidades.

Madam Hortensia followed her routine to a tee, until one day everything went wrong… what a disaster! A wonderful story, full of humor, about the importance of tackling new challenges. Do you dare to change?Madam Hortensia lives life in a straight line, never straying a step out of her daily routine.  Was she finicky? Not quite, she just liked everything to be perfectly to her liking. Her alarm clock rang every day at 07:18 sharp. Not one minute before, or one minute after. Then her planned routine would begin in extreme detail, and nothing could possibly go wrong. But one morning, her alarm does not go off on time and her life spins into a whirlwind. Suddenly, she finds herself doing entirely new things she has never tried before.With wit and charm, this delightful tale shares what happens when we learn to embrace change and open our minds to possibility.

Winner at the 2012 International Latino Book Awards. A superbly illustrated original story about the power of loving yourself and finding happiness.This is the story of Anastasia, a cockroach who dreamed of being accepted and becoming famous and important like her distant relatives the Egyptian beetles, sacred insects that everybody treated like royalty.Although it may seem impossible to believe, in another life Anastasia was a princess, transformed by a wave of the magic wand of Fairy Brunilda, who was determined to sow good wherever she went. But being a princess is not an easy task… Soon Anastasia began to feel out of place. She didn’t like life in the palace too much, and after following exciting adventures, Anastasia came to understand that being an ordinary, everyday cockroach wasn’t such a bad thing after all. Especially when, moved by her great heart, she managed to save the lives of an entire family of humans, everything without getting a hair out of place! What prize did Fairy Brunilda have in store for her as a reward for her generous actions?Ganador del International Latino Book Awards en 2012. Una historia original magníficamente ilustrada sobre el poder de quererse a uno mismo y de encontrar la felicidad.Anastasia es una cucaracha que soñaba con ser aceptada y convertirse en famosa e importante como sus parientes lejanos, los escarabajos egipcios, unos insectos sagrados que eran venerados por todo el mundo.Un día, el hada Brunilda, empeñada en hacer el bien a diestro y siniestro, la convirtió en una bellísima princesa con solo un simple movimiento de varita. Pero ser princesa no es tarea fácil… Pronto Anastasia empezó a sentir que ese no era su lugar. La vida en palacio no le gustaba demasiado, y tras vivir emocionantes aventuras, comprendió que lo de ser una cucaracha normal y corriente no estaba tan mal. Sobre todo cuando, movida por su enorme corazón, fue capaz de salvar la vida de una familia enterita de seres humanos, ¡y sin despeinarse un pelo! ¿Qué premio le tendría preparado el hada Brunilda por su generosa acción?

Winner at the 2012 International Latino Book Awards. A superbly illustrated original story about the power of loving yourself and finding happiness.This is the story of Anastasia, a cockroach who dreamed of being accepted and becoming famous and important like her distant relatives the Egyptian beetles, sacred insects that everybody treated like royalty.Although it may seem impossible to believe, in another life Anastasia was a princess, transformed by a wave of the magic wand of Fairy Brunhilda, who was determined to sow good wherever she went. But being a princess is not an easy task… Soon Anastasia began to feel out of place. She didn’t like life in the palace too much, and after following exciting adventures, Anastasia came to understand that being an ordinary, everyday cockroach wasn’t such a bad thing after all. Especially when, moved by her great heart, she managed to save the lives of an entire family of humans, everything without getting a hair out of place! What prize did Fairy Brunhilda have in store for her as a reward for her generous actions?

Joy, the elf, has gone missing from Mateo's life. The Ragdoll Witch has cast a spell to immediately grant each one of Mateo's wishes so that Joy is no longer needed. How will Mateo ever find Joy again?