Down Syndrome and Alzheimer's Disease

"'Significant, important, excellent. It provides a comprehensive 'state of the art' analysis. Not only is dementia in Alzheimer's disease emerging as the greatest challenge for those charged with the health and community care of people who are ageing with an intellectual disability; it is a similar challenge for the dramatically increasing numbers of older people in the general population. The scientific community investigating one of the most serious health challenges facing adults with an intellectual disability is indebted to Dr Vee Prasher and colleagues for this scholarly contribution to the study of the biological correlates of dementia in Alzheimer's disease in adults with Down syndrome. This important collection of the most recent research findings in this field of enquiry will further stimulate efforts to develop treatments that may ameliorate the condition; delay its onset, and ultimately provide means for prevention.' Trevor R Parmenter, in the Foreword"

• Overview of Alzheimer’s disease in Down syndrome. Neuropathology of Alzheimer’s disease in Down syndrome. Genetics, Alzheimer’s disease and Down syndrome. Amyloid beta and tau Proteins in Alzheimer’s disease and Down syndrome. Down syndrome, dementia, and superoxide dismutase. Macrocytosis: a peripheral marker for dementia in Alzheimer’s disease in adults with Down syndrome? Thyroid function, dementia and Down syndrome. Neurophysiological changes associated with dementia in Down syndrome. Neuroimaging studies of persons with Down syndrome. Concluding remarks