Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways

Häftad, Engelska, 2019

Del i serien Resistance to Targeted Anti-Cancer Therapeutics

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Beskrivning

This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression.

Produktinformation

Utgivningsdatum:2019-02-02
Mått:155 x 235 x undefined mm
Format:Häftad
Språk:Engelska
Serie:Resistance to Targeted Anti-Cancer Therapeutics
Antal sidor:242
Förlag:Springer Nature Switzerland AG
ISBN:9783030098179

Utforska kategorier

Onkologi inom Medicin

Mer om författaren

Yosef Yarden, PhD, is Professor, Department of Biological Regulation, The Weizmann Institute of Science, Israel.

Innehållsförteckning

Resistance of colorectal tumors to anti-EGFR antibodies.- Resistance of lung cancer to kinase inhibitors specific to EGFR or ALK.- Mechanisms of action and resistance of trastuzumab in breast cancer.- Mechanisms of resistance to molecular therapies targeting the HGF/MET axis.- RAF, MEK and ERK inhibitors as anti-cancer drugs: intrinsic and acquired resistance as a major therapeutic challenge.- Mechanisms of resistance to PI3K and AKT inhibitors.- Sensitivity and resistance to BH3 mimetics in cancer therapy.- Resistance mechanisms to cyclin-dependent kinase inhibitors.- Resistance to inhibitors of angiogenesis.