Clinician's Guide to Sperm DNA and Chromatin Damage

Häftad, Engelska, 2019

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Beskrivning

Finally, part V discusses current treatment options, such as antioxidant therapy, varicocelectomy, advanced sperm processing techniques and the use of testicular sperm. We are now beginning to better understand the unique organization of the sperm chromatin, as well as the nature and etiology of sperm DNA damage.

Produktinformation

Utgivningsdatum:2019-01-26
Mått:155 x 235 x 32 mm
Vikt:1 069 g
Format:Häftad
Språk:Engelska
Antal sidor:605
Förlag:Springer Nature Switzerland AG
ISBN:9783030101169

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Mer om författaren

Armand Zini, MD, FRCSC, Professor, Department of Surgery, Division of Urology, St. Mary’s Hospital Center, Montreal, Québec, CanadaAshok Agarwal, PhD, HCLD, Professor, Lerner College of Medicine of Case Western Reserve University, Director, Andrology Center, Director, American Center for Reproductive Medicine, Department of Urology, Cleveland Clinic Foundation, Cleveland, Ohio, USA

Innehållsförteckning

Sperm Chromatin: An Overview.- Sperm Nucleoproteins (Histones and Protamines).- Sperm Nuclear Architecture.- Sperm Chromatin Structure Assay (SCSA®): Evolution from Origin to Clinical Utility.- TUNEL Assay.- TUNEL Assay by Bench Top Flow Cytometer in Clinical Laboratories.- The Comet Assay.- Sperm Chromatin Dispersion (SCD) Assay.- Cytochemical Tests of Sperm Chromatin Maturity.- Is There an Optimal Sperm DNA Test?.- Oxidative Stress.- Apoptosis in Ejaculated Spermatozoa and in the Normal and Pathological Testes: Abortive Apoptosis and Sperm Chromatin Damage.- Defective Spermatogenesis and Sperm DNA Damage.- Sperm Chromatin and Lifestyle Factors.- Cancer and Sperm DNA Damage.- Sperm Chromatin and Environmental Factors.- Sperm DNA Damage and Oocyte Repair Capability.- Experimental Studies on Sperm DNA Fragmentation and Reproductive Outcomes.- Sperm DNA and Natural Pregnancy.- Sperm DNA and ART (IUI, IVF, ICSI) Pregnancy.- Sperm DNA and Pregnancy Loss after IVF and ICSI.- Sperm DNA Tests are Clinically Useful: Pro.- Sperm DNA Tests Are Clinically Useful: CON.- Antioxidant Therapy.- Varicocelectomy.- Physiological Intra-Cytoplasmic Sperm Insemination Based on Hyaluronic Acid Binding Ability.- Advanced Sperm Processing / Selection Techniques.- Use of Testicular Sperm for ICSI: Pro.- Debate on the Use of Testicular Sperm for ICSI: Con.- Strategies to Diminish DNA Damage in Sperm Samples used for ART.- Sperm DNA Testing: Where Do We Go from Here?