This book constitutes the refereed proceedings of the 22nd International Conference on Applications of Evolutionary Computation, EvoApplications 2019, held in Leipzig, Germany, in April 2019, co-located with the Evo*2019 events EuroGP, EvoCOP and EvoMUSART.The 44 revised full papers presented were carefully reviewed and selected from 66 submissions. They were organized in topical sections named: Engineering and Real World Applications; Games; General; Image and Signal Processing; Life Sciences; Networks and Distributed Systems; Neuroevolution and Data Analytics; Numerical Optimization: Theory, Benchmarks, and Applications; Robotics.