Lipid Signaling in Human Diseases

AvJulian Gomez-Cambronero,Michael A. Frohman

Inbunden, Engelska, 2020

Del i serien Handbook of Experimental Pharmacology

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Beskrivning

Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients.

Produktinformation

Utgivningsdatum:2020-04-25
Mått:155 x 235 x 25 mm
Vikt:694 g
Format:Inbunden
Språk:Engelska
Serie:Handbook of Experimental Pharmacology
Antal sidor:336
Förlag:Springer Nature Switzerland AG
ISBN:9783030336677

Utforska kategorier

Innehållsförteckning

Part 1. New Roles for Sphingolipid Signaling and Cell Function.- 1. Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma.- 2. Exploring the Therapeutic Landscape of Sphingomyelinases.- 3. Sphingosine kinases as druggable targets.- Part 2. Phospholipase D and Mitogen Phosphatidic Acid in Human Disease.- 4. Prospects for PLD inhibition in cancer and thrombotic disease.- 5. Phospholipase D and the Mitogen Phosphatidic Acid in Human Disease: Inhibitors of PLD at the Crossroads of Phospholipid Biology and Cancer.- 6. Role of Phospholipase D-Derived Phosphatidic Acid in Regulated Exocytosis and Neurological Disease.- Part 3. Lipid Kinases and Novel Regulatory Pathways.- 7. Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors.- 8. Functions of Nuclear Polyphosphoinositides.- Part 4. Bioactive Lipids in Health and Disease.- 9. Platelet-Activating Factor as an Effector for Environmental Stressors.- 10. Phospholipase D and Choline Metabolism.- Part 5- Lipids and Membrane Microdomains.- 11. Regulation of Inositol Biosynthesis: Balancing Health and Pathophysiology.- 12. Lipids and Membrane Microdomains: The Glycerolipid and Alkylphosphocholine Class of Cancer Chemotherapeutic Drugs.- Part 6. Nuclear Trafficking of Lipids.- 13. Inositide-Dependent Nuclear Signalling in Health and Disease.- 14. Lipids in Exosome Biology.