Interaction of Nanomaterials with the Immune System

Inbunden, Engelska, 2020

Del i serien Molecular and Integrative Toxicology

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Beskrivning

This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.

Produktinformation

Utgivningsdatum:2020-01-31
Mått:155 x 235 x 19 mm
Vikt:524 g
Format:Inbunden
Språk:Engelska
Serie:Molecular and Integrative Toxicology
Antal sidor:223
Upplaga:20001
Förlag:Springer Nature Switzerland AG
ISBN:9783030339616

Utforska kategorier

Onkologi inom Medicin
Teknik: allmänt inom Naturvetenskap och teknik
Farmakologi inom Medicin

Mer om författaren

James C. Bonner is Professor of Toxicology at North Carolina State University. His research focuses on the fibroproliferative effects of nanomaterials in the lung, particularly in susceptible disease models. Jared M. Brown is Professor of Toxicology at the University of Colorado Anschutz Medical Campus. His research focuses on allergic immune responses to nanomaterials and their application in medicine.

Innehållsförteckning

Overview of immune response to nanomaterials caused by either inhalation, oral, or dermal exposure.- Engineered nanomaterials: synthesis, characterization, uses and exposure.- Impact of nanomaterials on barrier function.- Complement activation and inflammation.- Macrophage function and phagocytosis.- Mast cells.- Impact on dendritic cell - lymphocyte function.- Impact on host pathogen response and microbiome.- Allergy/autoimmunity.- Pre-existing allergic or bacterial-induced lung disease.- Nanomaterial effects on viral infection.- Immunotoxicity and carcinogenesis.- In vivo animal models (nude mice, transgenic models).- In vitro cell culture models.- In silico computational modeling.- Summary of mechanisms of immune modulation.