Fungal Cell Wall

JP Latgé has been the Head of the Aspergillus Unit at Institut Pasteur in Paris for the last 20 years and is now Professor at Institute of Molecular Biology and Technology, Foundation for Research and Technology-Hellas (FORTH), Heraklion, Crete, Greece. His research career has been focused on the study of the biology of the human opportunistic fungal pathogen Aspergillus fumigatus through genetic, biochemical and immunological approaches. More precisely, studies are concentrated on the biosynthesis of the cell wall and associated extracellular matrix and the role of the components of these fungal structures during the fungal development in the immunocompetent and immunocompromised host. He has authored > 300 publications indexed in Pub Med, he is expert for several French and international grant review panels including ERC and has been the recipient of honors and key note speaker in multiple events in the Medical Mycology and Glycobiology fields.

• Synthesis of mimicks.- Melanin.- Rodlets and cell wall surface proteins.- Alpha 1,3 and Beta 1,3 glucans and remodelling.- Chitin.- Cell wall PAMPs and PRRs in mammalians.- Extracellular polysaccharides and biofilms.- Cell wall drugs and resistance mechanisms.- GPI proteins and cell wall.- Cell wall and morphogenesis.- Carbohydrate active enzymes in fungi B.- Glucanases and chitinases.- Respiration and cell wall synthesis.- Cell wall and environment.