Vasoplegic Endothelial Dysfunction

Paulo Roberto Barbosa EvoraGraduated in Medicine from the Ribeirão Preto School of Medicine, University of São Paulo – USP (1972). At the same institution, he completed residencies in General Surgery (1973) and Thoracic and Cardiovascular Surgery (1974), and a PhD also in General Surgery (1980). Dr. Evora was Coordinator of the Endothelial Function Laboratory of the Experimental Surgery Division and Collaborating Researcher in Cardiovascular Surgical Research at the Mayo Clinic, Rochester, MN, USA. Associate Professor (1994) and Full Professor (2004) of the Department of Surgery, Orthopedics and Traumatology at the Ribeirão Preto School of Medicine, USP (1993), clinical director of the Intensive Care Center at the Hospital das Clínicas of the Ribeirão Preto School of Medicine - USP, Coordinator of the postgraduate program (2004-2006), Vice-Head of the Department (2004-2006), Head of the Department (2007-2008), member of the Research Committee of the Ribeirão Preto School of Medicine, and member of the Bioterio Central Commission of the USP Ribeirão Preto Campus, and Editor-in-chief of the Brazilian Journal of Cardiovascular Surgery. Andrea Carla CelottoGraduated in Biomedicine from the University of Franca (2002), obtained a Master’s degree in Pharmaceutical Sciences from the Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - USP (2005), and completed a PhD in Sciences at the Ribeirão Preto School of Medicine - USP (2009). She also completed a PhD internship at the Vascular Biology Laboratory at Mayo Clinic, Rochester, MN, USA and a post-doctorate at the Endothelial Function Laboratory of the Department of Surgery and Anatomy at Ribeirão Preto School of Medicine - USP (2013). Former professor at the University of Franca, Dr. Celotto is currently a professor of the Faculty of Health Sciences of Barretos Dr. Paulo Prata and an Associate Researcher of the Department of Surgery and Anatomy, Ribeirão Preto School of Medicine – USP. She has extensive experience in Physiology, Pathophysiology and Pharmacology. Agnes Afrodite Sumarelli AlbuquerqueBachelor’s degree in Biological Sciences from Universidade Estadual Paulista Júlio de Mesquita Filho, Jaboticabal campus (2005) and specialization in Genetic Engineering and Molecular Biology (2009). She obtained a Master’s degree (2012) and completed a PhD (2018) in Morphology and Experimental Medicine Surgical Clinic. Laboratory Technician at the Department of Surgery and Anatomy of the Ribeirão Preto Medical School of the University of São Paulo. Patricia Martinez ÉvoraGraduated in Veterinary Medicine from the Universidade Estadual Paulista Júlio de Mesquita Filho, Jaboticabal campus (2008). Completed internships at Ohio State University, Columbus, OH, USA, in the fields of equine medical clinic and Molecular Biology (2008). She obtained a Master's degree in Veterinary Medicine (2012) and completed a PhD in Animal Pathology from the Universidade Estadual Paulista Júlio de Mesquita Filho, Jaboticabal campus (2017). Dr. Évora is currently a postdoctoral fellow in Immunoparasitology at the Ribeirão Preto School of Medicine - USP.

• Part I - General Conceptual Aspects.- Introduction.- Physiology of the Endothelium.- PART 2– PARTICULARITIES OF ENDOTHELIAL DYSFUNCTION IN DIFFERENT TYPES OF SHOCK.- Circulatory Shock: A Conceptual and Practical Approach.- Circulatory Shock, Ischemia Reperfusion Injury, Inflammatory Response Syndrome (SIRS) and Multiple Organ Failure.- Endothelial Dysfunction in Hemorrhagic Shock.- Endothelial Dysfunction in Cardiogenic Shock.- Endothelial Dysfunction in Distributive Shock.- PART 3– METHYLENE BLUE.- Methylene blue.- The Inhibition of Guanylate Cyclase by Methylene Blue as Therapeutic Proposal for Vasoplegia Associated with Shock.- Methylene Blue in the Treatment of Anaphylaxis.- Methylene Blue in Children and Neonates.- Methylene Blue and Burns.- Cardiac arrest and neuroprotection by methylene blue.- Methylene Blue and Endocarditis.- PART 4 – ENDOTHELIAL DYSFUNCTION IN SPECIFIC SITUATIONS.- Vasoplegic syndrome in heart surgery.- Vasoplegic Endothelial Dysfunction In Orthotopic Liver Transplantation.- Acid-base Balance.- The therapeutic use of inhaled nitric oxide.