This two-volume set of LNCS 13017 and 13018 constitutes the refereed proceedings of the 16th International Symposium on Visual Computing, ISVC 2021, which was held in October 2021. The symposium took place virtually instead due to the COVID-19 pandemic. The 48 papers presented in these volumes were carefully reviewed and selected from 135 submissions. The papers are organized into the following topical sections:Part I: deep learning; computer graphics; segmentation; visualization; applications; 3D vision; virtual reality; motion and tracking; object detection and recognition.Part II: ST: medical image analysis; pattern recognition; video analysis and event recognition; posters.