Nicolaus Kröger MD, is the current EBMT President, Professor of Medicine and Medical Director of the Department of Stem Cell Transplantation at the University Medical Center, Hamburg - Eppendorf, Germany John G. Gribben, MD DSc FRCP FRCPath, FMedSci, is the Past President of EHA, Professor of Medical Oncology and Director of Stem Cell Transplantation at Saint Bartholomew's Hospital, Queen Mary School of Medicine, University of London, UKChristian Chabannon, MD, PhD, is the current chair of the Cellular Therapy & Immunobiology Working Party (CTIWP) of the EBMT, is the Head and Qualified Person of the Cell Collection and Cell Processing Facility at Institut Paoli-Calmettes, the Coordinator of the "Centre d’Investigations Cliniques en Biothérapies de Marseille", and a Professor of Cell Biology at Aix-Marseille University, FranceIbrahim Yakoub-Agha, MD, PhD, is the current chair of the Chronic Malignancies Working Party of the EBMT and holds the position of coordinating professor for the Department of Hematology at Lille Faculty of Medicine, FranceHermann Einsele, MD, FRCP, is Full Professor of Internal Medicine and has been Director of the Department of Internal Medicine II of the University Hospital Würzburg, Germany

• 1. Introduction.- 2. The science behind CAR-T Cells.- 3. Manufacturing CAR-T Cells: the supply chain.- 4. Clinical indications for CAR-T Cells.- 5. Clinical management of patients treated with CAR-T Cells.-  6. Access to CAR-T cells.