This volume constitutes the refereed and revised post-conference proceedings of the 6th IFIP WG 5.15 International Conference on Information Technology in Disaster Risk Reduction, ITDRR 2021, in Morioka, Japan, in October 2021.The 11 full papers presented were carefully reviewed and selected from 18 submissions. The papers focus on various aspects and challenges of coping with disaster risk reduction. The papers are categorized in the following topical subheadings:  Information Analysis for Situation Awareness; Evacuation and Rescue; COVID-19 Issues; and IT Use for Risk and Disaster Management.