Voltage-Gated Calcium Channels

Häftad, Engelska, 2023

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Beskrivning

This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics.

Produktinformation

Utgivningsdatum:2023-11-10
Mått:178 x 254 x 39 mm
Vikt:1 330 g
Format:Häftad
Språk:Engelska
Antal sidor:710
Förlag:Springer International Publishing AG
ISBN:9783031088834

Utforska kategorier

Fysiologi inom Medicin
Tillämpad fysik inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik

Mer om författaren

Dr. Gerald Werner Zamponi is a Professor in the Department of Physiology and Biophysics, and Canada Research Chair in Molecular Neuroscience, at the University of Calgary, Calgary, Canada. Dr. Norbert Weiss is an Assistant Professor in the Department of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.

Innehållsförteckning

1. Measuring and manipulating calcium.- 2. Structure, function and subunit assembly of VGCC.- 3. Splice variation and RNA editing of VGCCs.- 4. Mechanisms of calcium channel permeation.- 5. Regulation by beta subunits .- 6. Regulation by alpha2 delta subunits.- 7. VGCCs in invertebrates.- 8. Modulation by GPCRs and second messengers.- 9. Trafficking of VGCCs.- 10. Calcium regulation.- 11. Calcium channel complexes with other channels.- 12. Regulation of gene transcription by VGCCs.- 13. Lessons from knock-out and knock-in mice.- 14. VGCCs and synaptic transmission.- 15. Cardiovascular syste.- 16. Calcium channels and exocytosis in chromaffin cells.- 17. Calcium channels in the pancreas in health and disease.- 18. Skeletal muscle system.- 19. Auditory and visual systems.- 20. Calcium channels and pain transmission.- 21. Migraine.- 22. Epilepsy.- 23. Psychiatric disorders.- 24. Parkinson’s disease.-25. Reproductive system.- 26. Cancer.- 27. Molecular determinants of VGCC pharmacology.- 28. Interactions with peptide toxins.- 29. Clinical pharmacology and drug discovery.