This book constitutes the refereed proceedings of the 16th International Conference on Provable Security, ProvSec 2022, held in Nanjing, China, in November 11–12,2022. The 15 full papers and 4 short papers were presented carefully reviewed and selected from 52 submissions. The papers focus on provable security as an essential tool for analyzing security of modern cryptographic primitives. They are divided in the following topical sections: Encryption; Lattice Based Cryptography; Information Security; Blockchain; and Foundations.