This book constitutes the refereed proceedings of the ​Second Workshop on Artificial Intelligence over Infrared Images for Medical Applications, AIIIMA 2023 held in conjunction with MICCAI 2023, held in Vancouver, BC, Canada, on October 2, 2023. The 10 full papers presented in this book were carefully peer reviewed and selected from 15 submissions. The second workshop on AIIIMA, similarily to the first, aimes to create a forum to discuss the specific sub-topic of AI over Infrared Images for Medical Applications at MICCAI and promote this novel area of research, that has the potential to hugely impact our society, among the research community.