This book constitutes the refereed proceedings of the 4th Latin American Workshop, LAWCN 2023, held in Envigado, Colombia, during November 28–30, 2023.The 8 full papers and 2 short papers included in this book were carefully reviewed and selected from 50 submissions. They were organized in topical sections as follows:artificial intelligence and machine learning; computational neuroscience; and brain-computer interfaces.