This book discusses several issues relevant to materials design and applications. The focus is on fundamental research and application areas in the field of the design and application of engineering materials, predominantly within the context of mechanical engineering applications. This includes a wide range of materials engineering and technology, including metals, e.g., lightweight metallic materials, polymers, composites, and ceramics. Advanced applications include manufacturing of new materials, testing methods, multi-scale experimental and computational aspects. The book publishes selected papers presented at the 5th International Conference on Materials Design and Applications 2024 (MDA 2024), held during July 4–5, 2024.