Antonio Cano is Professor of Obstetrics and Gynecology in Valencia, Spain. His research focuses on gynecological endocrinology, particularly on aspects related to women's health and aging. Professor Cano has published over 300 journal articles, some 150 additional articles or chapters in books, and has been the editor of 13 books.

• Part I: Biological Background.- 1. Menopause, a stage in the life of women.- 2. Menopause: the concepts and the biological background.- 3. Premature Ovarian Insufficiency.- Part II: Impact of Estrogen Depletion on Symptoms and Quality of Life.- 4. Clinical Symptoms and Quality of Life: Vasomotor Symptoms and Mood.- 5. Clinical symptoms and quality of life: insomnia and muscle/joint aches.- 6. Genitourinary Syndrome of the Menopause. Vaginal health and microbiota.- 7. Sexual Health.- Part III: The Impact of Estrogen Depletion on Disease Susceptibility.- 8. Postmenopausal osteoporosis.- 9. The metabolic syndrome during female midlife and beyond.- 10. The impact of estrogen decline on other noncommunicable diseases.- Part IV: Management of Menopause.- 11. Hormone therapy (I): Estrogens, progestogens and androgens.- 12. Hormone Therapy (II): Tibolone and The TSEC Concept.- 13. The effect of Menopause Hormone Therapy on climacteric symptoms.- 14. The impact of hormone therapy on other noncommunicable diseases. Central nervous system, cardiovascular tree, osteoarthritis and cancer.- 15. Non-hormonal management of the menopause.- 16. Complementary and alternative therapies for vasomotor symptoms during climacteric and beyond.- 17. Lifestyle: physical activity.- 18. Nutritional management of menopausal women.- Part V: Menopause in the Context of Healthy Ageing.- 19. Frailty and comorbidities. Frailty in women.- 20. Muscle strength, dynapenia, and sarcopenia during female midlife and beyond.- 21. Empowerment of women and lifestyle. The help of digital technologies.

Antonio Cano is Professor of Obstetrics and Gynecology in Valencia, Spain. His research focuses on gynecological endocrinology, particularly on aspects related to women's health and aging. Professor Cano has published over 300 journal articles, some 150 additional articles or chapters in books, and has been the editor of 13 books.

• Part I: Biological Background.- 1. Menopause, a stage in the life of women.- 2. Menopause: the concepts and the biological background.- 3. Premature Ovarian Insufficiency.- Part II: Impact of Estrogen Depletion on Symptoms and Quality of Life.- 4. Clinical Symptoms and Quality of Life: Vasomotor Symptoms and Mood.- 5. Clinical symptoms and quality of life: insomnia and muscle/joint aches.- 6. Genitourinary Syndrome of the Menopause. Vaginal health and microbiota.- 7. Sexual Health.- Part III: The Impact of Estrogen Depletion on Disease Susceptibility.- 8. Postmenopausal osteoporosis.- 9. The metabolic syndrome during female midlife and beyond.- 10. The impact of estrogen decline on other noncommunicable diseases.- Part IV: Management of Menopause.- 11. Hormone therapy (I): Estrogens, progestogens and androgens.- 12. Hormone Therapy (II): Tibolone and The TSEC Concept.- 13. The effect of Menopause Hormone Therapy on climacteric symptoms.- 14. The impact of hormone therapy on other noncommunicable diseases. Central nervous system, cardiovascular tree, osteoarthritis and cancer.- 15. Non-hormonal management of the menopause.- 16. Complementary and alternative therapies for vasomotor symptoms during climacteric and beyond.- 17. Lifestyle: physical activity.- 18. Nutritional management of menopausal women.- Part V: Menopause in the Context of Healthy Ageing.- 19. Frailty and comorbidities. Frailty in women.- 20. Muscle strength, dynapenia, and sarcopenia during female midlife and beyond.- 21. Empowerment of women and lifestyle. The help of digital technologies.

Antonio Cano is Professor of Obstetrics and Gynecology in Valencia, Spain. His research focuses on gynecological endocrinology, particularly on aspects related to women's health and aging. Professor Cano has published over 300 journal articles, some 150 additional articles or chapters in books, and has been the editor of 13 books.

• Part I: Biological Background.- 1. Menopause, a stage in the life of women.- 2. Menopause: the concepts and the biological background.- 3. Premature Ovarian Insufficiency.- Part II: Impact of Estrogen Depletion on Symptoms and Quality of Life.- 4. Clinical Symptoms and Quality of Life: Vasomotor Symptoms and Mood.- 5. Clinical symptoms and quality of life: insomnia and muscle/joint aches.- 6. Genitourinary Syndrome of the Menopause. Vaginal health and microbiota.- 7. Sexual Health.- Part III: The Impact of Estrogen Depletion on Disease Susceptibility.- 8. Postmenopausal osteoporosis.- 9. The metabolic syndrome during female midlife and beyond.- 10. The impact of estrogen decline on other noncommunicable diseases.- Part IV: Management of Menopause.- 11. Hormone therapy (I): Estrogens, progestogens and androgens.- 12. Hormone Therapy (II): Tibolone and The TSEC Concept.- 13. The effect of Menopause Hormone Therapy on climacteric symptoms.- 14. The impact of hormone therapy on other noncommunicable diseases. Central nervous system, cardiovascular tree, osteoarthritis and cancer.- 15. Non-hormonal management of the menopause.- 16. Complementary and alternative therapies for vasomotor symptoms during climacteric and beyond.- 17. Lifestyle: physical activity.- 18. Nutritional management of menopausal women.- Part V: Menopause in the Context of Healthy Ageing.- 19. Frailty and comorbidities. Frailty in women.- 20. Muscle strength, dynapenia, and sarcopenia during female midlife and beyond.- 21. Empowerment of women and lifestyle. The help of digital technologies.