Alberto Gobbi completed his residency in orthopedic surgery at the Medical Faculty of Milan University in 1988, and in Sports Medicine in Genoa, in 1992. He was one of the first Europeans to join the International Cartilage Repair Society and he worked for several years with the leading international experts in orthopedic surgery, arthroscopy and regenerative medicine. He founded OASI Bioresearch Foundation Gobbi Onlus (NPO), which is recognized as an international teaching center by ISAKOS and ICRS, and has dedicated his time to the education of hundreds of fellows over the last 20 years. He is the Past President of ICRS and Member of Board of Directors of Isakos. He worked as Visiting Professor at UCSD San Diego and was appointed as Honorary Professor at University of Beijing, Singapore and Seoul. Norimasa Nakamura is a Professor at the Institute for Medical Science in Sports at Osaka Health Science University and the Global Center for the Medical Engineering and Informatics at Osaka University. He is also an orthopedic surgeon at the Osaka University Hospital, specializing in arthroscopic surgery and sports medicine. His research focuses on joint-tissue repair, particularly the regeneration of cartilage, ligament, and meniscus. He has published over 150 peer reviewed scientific papers. John G. Lane is a Clinical Associate Professor-voluntary at the Department of Orthopedic Surgery, at the University of California, San Diego. Dr. Lane completed his residency at the University of Michigan and fellowship training in sports medicine at UCSD. He is a member of AAOS, AANA, AOSSM, ISAKOS and ICRS. Currently he is the chair of the ICRS membership committee and chairman of the ISAKOS education committee. His clinical field of practice focuses on complex knee and shoulder injuries and he is pursuing ongoing research into rotator cuff injury, the effect of diabetes and regeneration of articular cartilage. Dr. Ignacio Dallo is an Orthopaedic Surgeon Recertified as Qualified by the University of Buenos Aires and the Argentine Association of Orthopaedics and Traumatology. He published peer-reviewed articles, book chapters, and book translations. His work areas are Bio-Orthopaedics, Knee Arthroscopy, and Sports injuries. Dr. Ignacio Dallo collaborated with the International Olympic Committee Research Team at the Youth Olympic Games in Buenos Aires in 2018. He is a current member of the Education and Sports Medicine Committees for ISAKOS, NextGen Committee for ICRS, and International Committee for AANA. He is Associate Editor of the Journal of Cartilage and Joint Preservation and reviewer of the Journal of ISAKOS.

• PART 1: OVERVIEW 1. Regenerative Medicine: fact or fiction?.- 2. Natural healing: can we improve it?.- 3. MSCs: a new approach.- 4. Evidence-Based Use of Regenerative medicine.- 5. Biological therapies in regenerative sports medicine.- 6. Regulation and regenerative treatments.- 7. Biological Factors in maintaining joint health.- PART 2: BASIC SCIENCE 8. Stem cells: different families.- 9. Growth Factors in regenerative medicine.- 10. Multipotent adult progenitor cells.- 11. Preclinical evidence of MSC-derived exosomes.- 12. Introduction to the concept of secretome in orthopaedics.- 13. Micro-RNA in orthopaedics.- 14. Gene therapy in regenerative medicine.- 15. Aragonite off-the-Shelf Implant for Articular Cartilage in Early OA.- 16. Growth and maturation of articular cartilage.- PART 3: CLINICAL APPLICATION 17. Advances in meniscal tissue engineering. - 18. Orthobiologics in meniscus pathology.- 19. Regenerative Medicine in Tendon pathologies.- 20. New treatments for musculoskeletal diseases.- 21. New approach with Personalized Platelet Rich Plasma.- 22. Essential Considerations in Platelet-Rich Plasma Preparations with Emphasis on Platelet Dosing and Bioformulations. There is No One-Size Fits All Method.- 23. Use of new formulation in Hyaluronic Acid in regenerative medicine.- 24. Regenerative Medicine to Improve Skeletal Muscle Healing After Injury, Disease, & Aging.- 25. Early OA treatment using allogeneic human umbilical cord MSCs.- 26. Meniscus repair using synovial stem cells.- 27. Regenerative Medicine for Osteoarthritis of the Knee Using Cell Sheets..- 28. Adipose-derived cell based products for regenerative medicine.- 29. Orthobiologically augmented scaffolds in cartilage repair.- PART 4: FUTURE TRENDS.- 30. Biophysical stimulation in regenerative medicine.- 31. Biological products and biomaterials for tendon regeneration.- 32. iPS cell-based technology for joint resurfacing.- 33. Nanotechnologies, bio-materials, and scaffolds.34. Scaffold-free tissue engineering in osteochondral restoration.- 35. Biomarkers in regenerative medicine and bio-orthopaedics.

Alberto Gobbi completed his residency in orthopedic surgery at the Medical Faculty of Milan University in 1988, and in Sports Medicine in Genoa, in 1992. He was one of the first Europeans to join the International Cartilage Repair Society and he worked for several years with the leading international experts in orthopedic surgery, arthroscopy and regenerative medicine. He founded OASI Bioresearch Foundation Gobbi Onlus (NPO), which is recognized as an international teaching center by ISAKOS and ICRS, and has dedicated his time to the education of hundreds of fellows over the last 20 years. He is the Past President of ICRS and Member of Board of Directors of Isakos. He worked as Visiting Professor at UCSD San Diego and was appointed as Honorary Professor at University of Beijing, Singapore and Seoul. Norimasa Nakamura is a Professor at the Institute for Medical Science in Sports at Osaka Health Science University and the Global Center for the Medical Engineering and Informatics at Osaka University. He is also an orthopedic surgeon at the Osaka University Hospital, specializing in arthroscopic surgery and sports medicine. His research focuses on joint-tissue repair, particularly the regeneration of cartilage, ligament, and meniscus. He has published over 150 peer reviewed scientific papers. John G. Lane is a Clinical Associate Professor-voluntary at the Department of Orthopedic Surgery, at the University of California, San Diego. Dr. Lane completed his residency at the University of Michigan and fellowship training in sports medicine at UCSD. He is a member of AAOS, AANA, AOSSM, ISAKOS and ICRS. Currently he is the chair of the ICRS membership committee and chairman of the ISAKOS education committee. His clinical field of practice focuses on complex knee and shoulder injuries and he is pursuing ongoing research into rotator cuff injury, the effect of diabetes and regeneration of articular cartilage. Dr. Ignacio Dallo is an Orthopaedic Surgeon Recertified as Qualified by the University of Buenos Aires and the Argentine Association of Orthopaedics and Traumatology. He published peer-reviewed articles, book chapters, and book translations. His work areas are Bio-Orthopaedics, Knee Arthroscopy, and Sports injuries. Dr. Ignacio Dallo collaborated with the International Olympic Committee Research Team at the Youth Olympic Games in Buenos Aires in 2018. He is a current member of the Education and Sports Medicine Committees for ISAKOS, NextGen Committee for ICRS, and International Committee for AANA. He is Associate Editor of the Journal of Cartilage and Joint Preservation and reviewer of the Journal of ISAKOS.

• PART 1: OVERVIEW 1. Regenerative Medicine: fact or fiction?.- 2. Natural healing: can we improve it?.- 3. MSCs: a new approach.- 4. Evidence-Based Use of Regenerative medicine.- 5. Biological therapies in regenerative sports medicine.- 6. Regulation and regenerative treatments.- 7. Biological Factors in maintaining joint health.- PART 2: BASIC SCIENCE 8. Stem cells: different families.- 9. Growth Factors in regenerative medicine.- 10. Multipotent adult progenitor cells.- 11. Preclinical evidence of MSC-derived exosomes.- 12. Introduction to the concept of secretome in orthopaedics.- 13. Micro-RNA in orthopaedics.- 14. Gene therapy in regenerative medicine.- 15. Aragonite off-the-Shelf Implant for Articular Cartilage in Early OA.- 16. Growth and maturation of articular cartilage.- PART 3: CLINICAL APPLICATION 17. Advances in meniscal tissue engineering. - 18. Orthobiologics in meniscus pathology.- 19. Regenerative Medicine in Tendon pathologies.- 20. New treatments for musculoskeletal diseases.- 21. New approach with Personalized Platelet Rich Plasma.- 22. Essential Considerations in Platelet-Rich Plasma Preparations with Emphasis on Platelet Dosing and Bioformulations. There is No One-Size Fits All Method.- 23. Use of new formulation in Hyaluronic Acid in regenerative medicine.- 24. Regenerative Medicine to Improve Skeletal Muscle Healing After Injury, Disease, & Aging.- 25. Early OA treatment using allogeneic human umbilical cord MSCs.- 26. Meniscus repair using synovial stem cells.- 27. Regenerative Medicine for Osteoarthritis of the Knee Using Cell Sheets..- 28. Adipose-derived cell based products for regenerative medicine.- 29. Orthobiologically augmented scaffolds in cartilage repair.- PART 4: FUTURE TRENDS.- 30. Biophysical stimulation in regenerative medicine.- 31. Biological products and biomaterials for tendon regeneration.- 32. iPS cell-based technology for joint resurfacing.- 33. Nanotechnologies, bio-materials, and scaffolds.34. Scaffold-free tissue engineering in osteochondral restoration.- 35. Biomarkers in regenerative medicine and bio-orthopaedics.