This volume constitutes the proceedings of 1st International Conference on  Africa Data, Artificial Intelligence and Innovations, AFRI2 2025, in Koudougou, Burkina Faso, during February 27–28, 2025.The 14 full papers were presented in this volume were carefully reviewed and selected from 50 submissions. They focus on Artificial intelligence Application: Large language models (LLMs) ; Data Protection, Cybersecurity and system; Data analytic and Decision Making.