The two-volume set LNCS 16008 & 16009 constitutes the refereed conferenceproceedings of the 18th International Work-Conference on Advances in Computational Intelligence, IWANN 2025, held in A Coruña, Spain, during June 16–18, 2025.The 103 revised full papers presented in these proceedings were carefully reviewed and selected from 144 submissions. The papers are organized in the following topical sections:Part I: Advanced Topics in Computational Intelligence; AI:Bioinformatics and Biomedical Applications; ANN HW-Accelerators; Bio-Inspired Systems and Neuro-Engineering; Recent Advances in Deep Learning; Deep Learning Applied to Computer Vision, Healthcare and Robotics; and Emerging Methodologies in Time Series Forecasting.Part II: Explainable and Interpretable Machine Learning (xAI) with a Focus on Applications; General Applications of AI; ITOMAD – Intelligent Techniques for Optimization, Modeling, and Anomaly Detection; Machine Learning for 4.0 Industry Solutions; Machine Learning for Photovoltaic System Optimization and Control in Modern Energy Grids; New and future advances in BCI-based Spellers; and Social and Ethical aspects of AI.
