This book provides a comparative study, as well as an account of global history, of the philosophical discourse of mind, reason, and culture. It then enthrones the cosmopolitan doctrine of mind, reason, and culture. It provides an approach that supersedes both universalist approach and culturalist/multiculturalist approach and rehabilitates individual persons’ mind as the primary substances of the human mind and thus primary thinking entities. The book develops a new concept of the relationship between reason and culture as part of the relationship between a substance-attribute, subject-predicate relationship, and as part of the relationship between the human mind and culture, as well as part of the humanity-culture-nature triangle relationship. It provides an alternative view both to universalism and culturalism/multiculturalism—the two dominating “isms” in approaching human reason and culture hitherto in both Eastern and Western philosophy--and emphasizes reading original philosophical classics in both Western and Chinese philosophies.