This book constitutes the refereed proceedings of the 4th International Workshop on Computational Mathematics Modeling in Cancer Analysis, CMMCA 2025, held in Daejeon, South Korea, during September 27, 2025, in conjunction with MICCAI 2025.The 17 full papers presented in this book were carefully reviewed and selected from 24 submissions. These papers focus on algorithmic and mathematical innovations that advance cancer imaging and analysis across spatial, temporal, and biological scales.
