This book constitutes the refereed proceedings of the 8th International Workshop on Predictive Intelligence in Medicine, PRIME 2025, held in conjunction with the 28th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2025, in Daejeon, South Korea, on September 27, 2025. The 21 full papers presented in this book were carefully reviewed and selected from 27 submissions. The proceedings focus on up to date research on predictive models with application to medical data.