This book constitutes the refereed proceedings of the 27th International Workshop on Computer Algebra in Scientific Computing, CASC 2025, which took place in Dubai, United Arab Emirates, during November 24–28, 2025.The 22 full papers and included in this book were carefully reviewed and selected from 36 submissions.  They focus on all aspects of computer algebra, symbolic computation, scientific computing, and related fields, alongside the country’s strategic focus on advancing research and establishing itself as a regional hub and global leader in scientific computing.