This two-volume set, LNAI 16301 and LNAI 16302, constitutes the refereed proceedings of the 45th SGAI International Conference on Artificial Intelligence, AI 2025, held in Cambridge, UK, during December 16-18, 2025.The 47 full papers and 20 short papers presented in these two volumes were carefully reviewed and selected from 93 submissions. The papers are grouped into these topical sections: Part I: Technical Papers; Deep Learning; Large Language Models; Machine Learning; Neural Networks; Techniques of AI and Short Technical Papers.Part II: Application Papers; Evolutionary Algorithms; Machine Learning; Neural Networks; Medical Computing and Health Informatics; Large Language Models; Natural Language Processing and Machine Vision; Applications of Artificial Intelligence and Short Application Papers.
