This book constitutes the refereed proceedings of the 14th Latin-American Symposium on Dependable and Secure Computing, LADC 2025, which took place in Valparaiso, Chile, during October 27-31, 2025.The 17 full papers included in the proceedings were carefully reviewed and selected from 34 submissions. They were organized in topical sections as follows: Security Foundations and Compliance; AI for Security and Dependability; Consensus, Cryptography, and Blockchain; Modeling and Dependability Evaluation; Advances in Dependable and Secure Computing; Monitoring and Critical Infrastructures; Industry Track,  and Student Forum.