Rare and Uncommon Gynaecological Cancers

Professor Nicholas Reed is a consultant Clinical Oncologist based at the Beatson Oncology Centre in Glasgow, Scotland. He has been a consultant oncologist for more than 25 years and is involved in the delivery of both chemotherapy and radiation treatment for patients with gynaecological, thyroid and neuroendocrine cancers. He has also been committed to the management of rare gynaecological cancers: he was a facilitator for the Gynaecological Cancer InterGroup Rare Tumour sub-group and is currently active in the UK in establishing database, registry and guidelines for these tumours.Dr. John Green is a Senior Lecturer in Cancer Studies at the University of Liverpool, England. He has been involved in the management of gynaecological cancers for 30 years and has been a principal investigator for numerous trials. He has also had a strong commitment to support translational research studies in gynaecological tumours. He has been activelyinvolved in the UK National Cancer Research Institute Gynaecological Cancer Study Group, the EORTC Gynaecological Cancer Group and the Gynaecological Cancer InterGroup. Professor David Gershenson from the MD Anderson Hospital in Texas is one of North America’s most distinguished Gynaecological Oncologists and has published very extensively on gynaecological cancers. His many publications include expert papers on granulosa and sex cord tumours, germ cell tumours, borderline ovarian tumours and other rarer gynaecological cancers. He is a former editor of Gynaecological Oncology and a very senior and active member of the Gynaecological Oncology Group. Dr. Nadeem Siddiqui is a consultant Gynaecological Oncologist based at Glasgow Royal Infirmary in Scotland. He has been a consultant for over 25 years and has been involved in the surgical treatment of gynaecological cancers. Currently his main area of interest is vulval cancer. He has previously been an active member of the EORTC gynaecological cancer group and the Gynae Cancer Intergroup.Professor Jean Calleja-Agius is an obstetrician and gynaecologist who studied both in Malta and at University College London and is currently a professor at the Faculty of Medicine and Surgery at the University of Malta. She has chaired the GYNOCARE COST Action (CA18117 – www.gynocare.net), which is a European network for Gynaecological Rare Cancer research: From Concept to Cure. This Action was funded by the European Union and was the first to bring experts from over 30 countries in order to coordinate information gathering on relevant basic and translational research lines and clinical trials in order to develop strategic research lines in the field of gynaecological rare cancer. Through her leadership, Prof Calleja-Agius has helped to coordinate best practices and standard operating procedures needed for biobanking together with legal requirements to support international trials in rare gynaecological cancers.Professor C. Simon Herrington is a Professor of Pathology, University of Edinburgh and Consultant Pathologist, NHS Lothian. His main research interest is pathological aspects of ovarian tumours, as part of the Nicola Murray Centre for Ovarian Cancer Research, with current projects including the molecular investigation of high-grade serous, low grade serous, endometrioid and clear cell ovarian carcinomas. He is the Editor in Chief of The Journal of Pathology: Clinical Research. His research interests are aligned with his clinical practice in gynaecological pathology as a Consultant Pathologist with NHS Lothian.

• . Part 1: Introduction.- 1.Introduction.- 2. Epidemiology and Data Bases , Cancer registries.- 3. Molecular stratification in gynaecological cancer and its clinical application.- 4. The role of Molecular profiling  .- 5. Imaging Rare and Uncommon Cancers.- . Part  2: Ovarian Tumours.- 6. Mucinous Tumours of the ovary.- 7. Pseudomyxoma peritonei.- 8. Clear Cell cancers  of the  Ovary.- 9. Borderline Ovarian tumours.- 10. Low Grade Serous Ovarian Tumours.- 11. Malignant Germ Cell Tumours.- 12. Neuroendocrine tumours of the  ovary.- 13. Sex cord and stromal tumours .- . Part 3: Uterine Tumours.- 14. Leiomyosarcomas  of the  uterus and  broad ligament.- 15. Endometrial Stromal sarcomas  .- 16. High Grade and Undifferentiated Uterine sarcomas.- 17. Adenosarcoma and ASSO.- 18. Clear cell tumours of the  Uterus.- 19. Miscellaneous Uterine tumours (PECOMA, FATWO & UTROSCT).- . Part 4 Cervix vagina and Vulva.- 20. Non HPV Related  cervical cancers.- 21. Small cell and  Neuroendocrine cancers.- 22. Primary Melanomas of Vagina and Vulva.- 23. Paget’s disease of  Vulva.- 24. Sarcomas and other rare vulval and  vaginal cancers.- . Part 5: Miscellaneous Topics.- 25. Paediatric Gyn Tumours.- 26. Trophoblastic Tumours.- 27. Fertility Preservation.- .Part 6: Concluding Chapter.- 28. The way Forward.