This book constitutes the refereed proceedings of the 4th International Conference on Transdisciplinary Multispectral Modelling and Cooperation for the Preservation of Cultural Heritage Addressing World Challenges, TMM-CH 2025, held in Athens, Greece during April 7-9, 2025.The 38 full papers included in this volume were carefully reviewed and selected from 477 submissions. They were categorized under the topical sections as follows: Developments in Digital Heritage; Utilization of IT and Digital Technologies for Sustainable Preservation, Revealing and Management of Cultural Heritage; and Digital Technologies for the Evaluation of the Resilience of Cultural Heritage Assets to Climate Change and Natural Hazards.