This book constitutes the proceedings of the Second MICCAI Challenge, CARE 2025, held in Conjunction with MICCAI 2025, in Daejeon, South Korea, on September 23, 2025. The 23 full papers in this book were carefully reviewed and selected from 51 submissions.These tracks aim to advance real-world medical image computing by bridging the gap between AI model development and practical clinical applications.

This book constitutes the proceedings of the Second MICCAI Challenge, CARE 2025, held in Conjunction with MICCAI 2025, in Daejeon, South Korea, on September 23, 2025. The 23 full papers in this book were carefully reviewed and selected from 51 submissions.These tracks aim to advance real-world medical image computing by bridging the gap between AI model development and practical clinical applications.

This book constitutes the proceedings of the Second MICCAI Challenge, CARE 2025, held in Conjunction with MICCAI 2025, in Daejeon, South Korea, on September 23, 2025. The 23 full papers in this book were carefully reviewed and selected from 51 submissions.These tracks aim to advance real-world medical image computing by bridging the gap between AI model development and practical clinical applications.