This book constitutes the refereed proceedings of the 4th International Conference on Computing, Communication and Learning, CoCoLe 2025, held in Rourkela, India, during September 22–24, 2025.The 38 full papers included in this book were carefully reviewed and selected from 153 submissions. They were organized in topical sections as follows: AI Innovations for Smart Systems; AI Innovations for Healthcare and Security; AI Innovations for Data and Vision; and AI Innovations for Real-World Systems.
