This volume presents selected, peer-reviewed contributions from the 12th International Congress of the European Union for Systemics (UES–EUS 2025), exploring the socio-ecological, epistemological, and governance implications of artificial intelligence across architectural, urban, and territorial systems.Bringing together interdisciplinary perspectives from systems theory, architecture, computer science, urban studies, and sustainability research, the book examines how artificial intelligence reshapes decision-making, knowledge production, and socio-technical transitions in both built and natural environments. The chapters address themes such as human–AI interaction, digital heritage and HBIM, urban governance and infrastructure, socio-ecological resilience, and methodological advances in systemic and computational modeling.Intended for researchers, practitioners, and advanced students, this proceedings volume provides an integrative and critical framework for understanding the role of artificial intelligence in shaping sustainable, adaptive, and inclusive governance futures.