This book presents the results from the 2nd Olympiad in Engineering Science (OES2025), with the focus on the transformative role of Artificial Intelligence and Machine Learning in engineering and biomedical sciences. It showcases applications that range from structural health monitoring and robotics control to biomedical diagnostics and 3D data acquisition. By integrating computational intelligence with experimental methods, the chapters demonstrate how AI-driven technologies are reshaping engineering design, monitoring systems, and medical innovations, providing a forward-looking perspective on how intelligent systems are revolutionizing both industrial and healthcare domains.