Radiopharmaceutical Chemistry

Inbunden, Engelska, 2026

3 064 kr

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Beskrivning

This new edition is a fully updated and comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. This new edition addresses the latest advancements in the field.The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like “The Production of Radionuclides” and “Basics of Radiochemistry”. The second section is the main focus of the book. In this section, each chapter’s author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a “Best of the Rest” chapter to cover emerging radionuclides. A new chapter on 11C - Next Generation Methods has been added to this edition. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including three new chapters on improving the pharmacokinetics of radiopharmaceuticals, artificial intelligence in radiopharmaceutical chemistry, and automation in radiochemical synthesis.This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas.

Produktinformation

Utgivningsdatum:2026-07-17
Mått:210 x 279 x undefined mm
Format:Inbunden
Språk:Engelska
Antal sidor:1 020
Upplaga:2
Förlag:Springer Nature Switzerland AG
ISBN:9783032264756

Utforska kategorier

Nuklearmedicin inom Medicin

Mer om författaren

Jason S. Lewis, PhDMemorial Sloan Kettering Cancer CenterNew York, NYUSA A.D. Windhorst, PhDAmsterdam University Medical CenterAmsterdamThe Netherlands Brian M. Zeglis, PhDHunter College, City University of New YorkNew York, NYUSA

Innehållsförteckning

Part I: First Principles.- Why Nuclear Imaging and Radiotherapy.- History of Nuclear Medicine.- Basics of Radiochemistry.- The Production of Radioisotopes.- Overview of Targeted Radiotherapy.- Overview of Nuclear Imaging.- Overview of Small Molecules as Radiopharmaceutical Vectors.- Overview of Peptides as Radiopharmaceutical Vectors.- Overview of Immunoglobulins as Radiopharmaceutical Vectors.- Overview of Nanoparticles as Radiopharmaceutical Vectors.- Part II: Radiochemistry.- 11C - Focus on 11CO2.- 11C - Focus on Everything Else.- 11C Next Generation Methods.- 13N and 15O.- 111In and 68Ga.- 18F Part 1: Nucleophilic Fluorinations.- 18F Part 2: Electrophilic Fluorinations.- 18F Part 3: Next Generation Methods.- 99mTc.- The Isotopes of Cu.- The Isotopes of Y and 177Lu.- 89Zr.- Radiohalogens.- The chemistry of 225Ac, 223Ra, and 212Pb.- The Best of the Rest: The Chemistry of Emerging Radionuclides.- Part III: Special Topics.- Bioconjugation Methods.- Click Chemistry in Radiochemistry.- Improving the Pharmacokinetics of Radiopharmaceuticals.- Radiochemical Instrumentation.- Introduction to Medical Physics and Kinetic Modeling.- Introduction to Radiation Safety.- Introduction to Biostatistics.- Choosing a Target for Nuclear Imaging or Radiotherapy.- Target Identification and Isolation.- Artificial Intelligence in Radiopharmaceutical Chemistry.- Preclinical Experimentation (Oncology).- Preclinical Experimentation (Neurology).- Automation in Radiochemical Synthesis.- The Clinical Translation Process in the U.S.- The Clinical Translation Process in Europe.- Setting up a Production Facility.