This book explores the fundamental importance of Extracellular Matrix (ECM) remodeling and deposition in health and disease. By understanding the intricate roles of ECM proteins and remodeling enzymes in mediating pathophysiological processes, it is possible to link the molecular mechanics of the ECM across various organs and tissues. This knowledge is essential for developing new therapeutic strategies for diseases linked to abnormal ECM remodeling and deposition.Key topics discussed include the ECM's interaction with the immune system and resident cells that lead to tissue fibrosis, malignant growth, and musculoskeletal pathology. The book emphasizes the advantages of using big data and systems biology approaches in understanding the diverse roles and properties of ECM remodeling.The contributors are leading authors in the field of matrix biology who created a paradigm-shift in experimental designs enabling linking molecular detail and system biology of pathophysiological ECM remodeling, synthesis and deposition with significant impact on basic and clinical research.The book is ideal for researchers, scholars and practitioners in the fields of matrix biology, immunology and pathology. It provides valuable insights into the ECM's role in disease onset and progression, paving the way for innovative treatments and interventions.
