This book constitutes the proceedings of the second Trauma Thompson Challenge, TTC 2025, and the first real-time tumor tracking for MRI-guided radiotherapy challenge, TrackRAD 2025, held in conjunction with MICCAI 2025, in Daejeon, South Korea on September 23, 2025.The 7 papers included from the TrackRAD 2025 Challenge and the 5 full papers included from the Trauma Tompson Challenge were carefully reviewed and selected from 24 and 22 final submissions accordingly.
