This book has been developed over numerous iterations within the Brigham and Women’s Hospital to provide the most critical information for trainees and physicians, and thus it represents a truly practical guidebook for anyone who needs the key information on the diagnosis, management and prevention of venous thromboembolism. Specific areas of focus include understanding the risk factors for VTE and the role of the right ventricle in PE pathophysiology. Efficient algorithms for diagnosis and exclusion of DVT and PE are emphasized. An state-of-the-art review of current techniques for the management of high risk VTE, including submassive and massive PE, is presented. The novel oral anticoagulants are revolutionizing the way VTE is treated and are covered in detail.​