This book constitutes the refereed proceedings of the 22ndInternational Symposium on Methodologies for Intelligent Systems, ISMIS 2015,held in Lyon, France, in October 2015.The 31 revised full papers presented together with 18short papers were carefully reviewed and selected from 67 submissions. Thepapers are organized in topical sections on data mining methods; databases,information retrieval, recommender systems; machine learning; knowledgerepresentation, semantic web; emotion recognition, music information retrieval;network analysis, multi-agent systems; applications; planning, classification;and textual data analysis and mining.