This book constitutes the refereed proceedings of the 16th International Conference on Software Reuse, ICSR 2017, held in Salvador, Brazil, in May 2017.The 8 revised full papers presented together with 3 short papers and 2 keynote presentations were carefully reviewed and selected from 34 submissions. The papers are grouped in topical sections on documentation reuse and repositories; software product lines; variability management and model variants; verification and refactoring for reuse; tools demonstrations; doctorial symposium; tutorials; and workshop.