This book constitutes the refereed proceedings of the 4th International Conference on Tools and Methods for Program Analysis, TMPA 2017, Moscow, Russia, March 3-4, 2017.The 12 revised full papers and 5 revised short papers presented together with three abstracts of keynote talks were carefully reviewed and selected from 51 submissions. The papers deal with topics such as software test automation, static program analysis, verification, dynamic methods of program analysis, testing and analysis of parallel and distributed systems, testing and analysis of high-load and high-availability systems, analysis and verification of hardware and software systems, methods of building quality software, tools for software analysis, testing and verification.