Stress Response of Critical Illness: Metabolic and Hormonal Aspects

Jean-Charles Preiser is currently Professor at the Department of Intensive Care of the Erasme University Hospital in Brussels. He has a long-lasting involvement in clinical research, in relation with the metabolic and nutritional aspects of critical illness. He published about 200 peer-reviewed articles, guidelines and book chapters. He is currently the associate editor of the Journal of Parenteral and Enteral Nutrition (JPEN), Critical Care and The Annals of Intensive Care and is actually involved in international and national education programs on nutrition.

“The last decade has seen dramatic evolution in our understanding of the metabolic response to critical illness and its management. This book provides a summary of this work. Senior trainees in critical care or practitioners in high acuity units are an appropriate audience for this book, written by authors from Europe and North America. … This is a worthy summary of the recent work in metabolic and endocrine response to various insults.” (David J. Dries, Doody’s Book Reviews, July, 2016)

• Foreword.- Introduction.- Part 1: Metabolic changes.- Successive phases.- Bioenergetics of the stress response.- Hibernation and mitochondrial adaptation.- Resistance to anabolic signals.- Use of lipids as energy substrates.- Use of carbohydrates.- Stress hyperglycemia.- Protein metabolism.- Micronutrients.- Part 2: Hormonal regulation.- Hypothalamic-pituitary axis.- Thyroid.- Adrenal.- Sex hormones.- Enterohormones.- Adipokines.- Part 3: Particular clinical situations.- Severe undernutrition.- Traumatic brain injury.- Sepsis and MOF.- Morbid obesity.- Burn injury.