Petar Mamula, MD Associate Professor of Pediatrics, The Children's Hospital of Philadelphia, Division of GI, Hepatology & Nutrition, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA Andrew B. Grossman, MDCo-Director, Center for Pediatric Inflammatory Bowel Disease, The Children's Hospital of Philadelphia, Division of GI, Hepatology & Nutrition , Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USARobert N. Baldassano, MD Director, Center for Pediatric Inflammatory Bowel Disease, The Children's Hospital of Philadelphia, Division of GI, Hepatology & Nutrition, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA< USAJudith R. Kelsen, MD The Children's Hospital of Philadelphia, Division of GI, Hepatology & Nutrition, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USAJonathan E. Markowitz, MD, MSCE Clinical Professor of Pediatrics, University of South Carolina School of Medicine - Greenville Chief, Division of Pediatric Gastroenterology & Nutrition, Greenville Health System, Greenville, SC, USA

“This book is intended for all practitioners who care for or are involved in the care of these complex patients. … this book provides clinically applicable information for primary care providers to pediatric subspecialists. … This is an excellent resource. The editors have done a great job of recruiting a group of authors who are leaders in this field and have organized the book in a logical and progressive fashion.” (Vincent Biank, Doody's Book Reviews, September, 2017)

• Genetics of Inflammatory Bowel Diseases.- The Intestinal Immune System During Homeostasis and Inflammatory Bowel Disease.- Cytokines and Inflammatory Bowel Disease.- The Gut Microbiota and Inflammatory Bowel Disease.- Immune Dysregulation Associated with Very Early-Onset Inflammatory Bowel Disease.- Epidemiology of Pediatric Inflammatory Bowel Disease.- The Natural History of Crohn Disease in Children.- Natural History of Ulcerative Colitis in Children.- Natural History of Pediatric Indeterminate Colitis.- Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease.- Liver Disease in Pediatric Inflammatory Bowel Disease.- Growth Impairment in Pediatric Inflammatory Bowel Disease.- Inflammatory Bowel Diseases and Skeletal Health.- Puberty and Pediatric-Onset Inflammatory Bowel Disease.- Classification of Inflammatory Bowel Disease in Children.- The History and Physical Exam.- Differential Diagnosis of Inflammatory Bowel Disease.- Laboratory Evaulation of Inflammatory Bowel Disease.- Fecal Biomarkers in Inflammatory Bowel Disease.- Radiologic Evaulation of Pediatric Inflammatory Bowel Disease.- Endoscopy and Inflammatory Bowel Disease.- The Pathology of Chronic Inflammatory Bowel Disease.- Video Capsule Endoscopy in Inflammatory Bowel Disease.- Bone Health in Pediatric Inflammatory Bowel Disease.- 5-Aminosalicylate Therapy.- Antibiotic Therapy.- Nutritional Management of Inflammatory Bowel Disease.- Probiotic Therapy.- Corticosteroids.- 6-Mercaptopurpine Therapy.- Methotrexate.- Infliximab Therapy for Pediatric Crohn Disease and Ulcerative Colitis.- Anti-TNF Biologic Therapies Other Than Infliximab.- Therapeutic Drug Monitoring in Pediatric Inflammatory Bowel Disease.- New Non-anti-TNF Therapies for the Treatment of Inflammatory Bowel Disease.- Medical Treatment of Perianal Crohn’s Disease Fistulae.- Treatment of Acute Severe Ulcerative Colitis.-  Dietary Therapies for Inflammatory Bowel Disease.- Complementary and Alternative Therapies.- Management of Intraabdominal Complications of Inflammatory Bowel Disease.- Surgical Management of Crohn Disease in Children.- Surgical Treatment of Ulcerative Colitis.- Postoperative Surveillance and Management of Crohn’s Disease.- Pouchitis After Ileal Pouch-Anal Anastomosis.- Enteral Feeding Devices and Ostomies.- Clinical Indices for Pediatric Inflammatory Bowel Disease Research.- Clinical Trials (Clinical Perspective).- Clinical Trials (Industry/Regulatory Perspective).- Infectious Complications of Pediatric Inflammatory Bowel Disease.- Psychological Aspects of Inflammatory Bowel Disease in Children and Adolescents.- Measurement of Quality of Life in Pediatric Inflammatory BOwel Disease.- Irritable Bowel Syndrome and Functional GI Disorders in Inflammatory Bowel Disease.- Inflammatory Bowel Disease in Pregnancy.- Immunizations in the Child with Inflammatory Bowel Disease.- Malignant Tumors Arising in Inflammatory Bowel Disease.- Quality Improvement in Inflammatory Bowel Disease.- Fostering Self-Management and Patient Activation.- Advocacy for Pediatric Patients with Inflammatory Bowel Disease.- Legislative Advocacy.- Transition from Pediatric to Adult Care.