This book constitutes the thoroughly refereed post-conference proceedings of the 5th International Symposium on Combinatorial Optimization, ISCO 2018, held in Marrakesh, Marocco, in April 2018. The 35 revised full papers presented in this book were carefully reviewed and selected from 75 submissions.

This book constitutes the thoroughly refereed post-conference proceedings of the 5th International Symposium on Combinatorial Optimization, ISCO 2018, held in Marrakesh, Marocco, in April 2018. The 35 revised full papers presented in this book were carefully reviewed and selected from 75 submissions.