Homologation Reactions

Reagents, Applications, and Mechanisms, 2 Volume Set

Inbunden, Engelska, 2023

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Beskrivning

Provides a unique summary of homologation strategies in organic synthesis Homologation Reactions presents different concepts underpinning the use of homologating reagents as well as their applications in organic synthesis. It covers in-depth discussions on the rationales governing this kind of transformations with a strong emphasis on mechanistic elements modulating critical aspects (e.g. selectivity) of the processes. In addition, this two-volume work features: Metal carbenoids, ylides, and diazo reagentsHomologating agents working under nucleophilic, electrophilic, and radical regimeHomologations realized on boron-containing or carbon-centered linchpinsUse of highly sensitive fluorinated homologating agentsProgressive homologations and the concept of assembly line synthesisHomologation processes followed by rearrangement cascadesConstruction of cyclic motifs and ring-expansionHomologation reactions with carbon monoxide and carbon dioxideNew and/or challenging directions to expect in the futureWritten by an international team of leaders in the field, the book is a useful guide for designing effective transformations by using homologation reactions. It is a must-read for every synthetic chemist in academia and industry!

Produktinformation

Utgivningsdatum:2023-07-19
Mått:173 x 249 x 56 mm
Vikt:2 064 g
Format:Inbunden
Språk:Engelska
Antal sidor:960
Förlag:Wiley-VCH Verlag GmbH
ISBN:9783527348152

Utforska kategorier

Organisk kemi inom Naturvetenskap och teknik

Mer om författaren

Vittorio Pace is Full Professor of Organic Chemistry at the University of Torino, Italy, since 2020. Before, he held a tenure-track professorship in Drug Synthesis at the University of Vienna, Austria. He received his habilitation (venia docendi) in Pharmaceutical Chemistry from the University of Vienna in 2016. He has been the recipient of different awards including the Ciamician Medal of the Italian Chemical Society, La Roche-Hoffmann Prize of the European Society of Medicinal Chemistry, the Thieme Award, and the Habilitation Award of the Austrian Chemical Society. Prof. Pace is an elected member of the Royal Spanish Academy of Pharmacy. His research is focused on the design and development of new synthetic concepts with functionalized organometallic reagents with a strong focus on homologation sequences.

Innehållsförteckning

Foreword PrefaceAcknowledgmentsVOLUME 11 Diazo-Mediated Homologation Reactions2 Lithium Carbenoids in Homologation Chemistry3 Streamlining C1 Homologation Reactions Using Continuous Flow Technology: Focus on Diazomethane and Methyllithium Chemistry4 Magnesium Carbenoids in Homologation Chemistry5 Homologation Reactions Based on Zinc Carbenoids and Related Reagents6 Homologations via Carbene-Mediated Rearrangement Reactions7 Oxenoids as Homologation Partners8 Sulfur Ylides as C1 Homologating Reagents9 Modern Homologation Reactions of Sulfoxonium Ylides via C-H Activation10 Phosphorus Reagents for Two-, Three-, and Four-Carbon Homologation of Carbonyl Compounds to Functionalized Olefins11 Homologation Tactics with Diborylmethane via alpha-Boryl CarbanionsVOLUME 212 Homologation of Boronic Acids and Organoboranes by Transition-Metal-Free Reactions with Diazo Compounds and N-Sulfonylhydrazones13 Stereospecific Reagent-Controlled Homologation Using Carbenoids Generated by Sulfoxide-Metal Exchange14 Iterative Homologation of Boronic Esters: Assembly Line Synthesis15 Fluorocarbon Chain Homologation and Elongation Reactions16 Homologation Reactions for the Synthesis of Fluorinated Molecules17 Synthesis of Oxiranes and Aziridines from Aldehydes and Imines Using Anionic Homologation Approaches18 One-Carbon Homologation and Homologation-Functionalization Reactions of Aldehydes19 Ring Expansion Homologation: Synthetic Strategies and Reaction Design20 Dehomologations and Ring Contraction Strategies21 Direct Radical C1 Homologations22 Allenation of Terminal Alkynes for Allene Synthesis23 Homogeneous Carbon Monoxide Homologation24 Homologation Reactions with Carbon Dioxide