This book constitutes the thoroughly refereed post-conference proceedings of the 6th International Conference on Learning and Intelligent Optimization, LION 6, held in Paris, France, in January 2012. The 23 long and 30 short revised papers were carefully reviewed and selected from a total of 99 submissions. The papers focus on the intersections and uncharted territories between machine learning, artificial intelligence, mathematical programming and algorithms for hard optimization problems. In addition to the paper contributions the conference also included 3 invited speakers, who presented forefront research results and frontiers, and 3 tutorial talks, which were crucial in bringing together the different components of LION community.
